Comprehensive Chemical Profiling and Multidirectional Biological Investigation of Two Wild Anthemis Species (Anthemis tinctoria var. Pallida and A. cretica subsp. tenuiloba): Focus on Neuroprotective Effects

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dc.authorid0000-0001-6548-7823
dc.authorid0000-0001-9431-9407
dc.authorid0000-0002-0797-6087
dc.authorid0000-0003-3962-8666
dc.authorid0000-0002-7346-7395
dc.contributor.authorOrlando, Giustino
dc.contributor.authorZengin, Gökhan
dc.contributor.authorFerrante, Claudio
dc.contributor.authorRonci, Maurizio
dc.contributor.authorRecinella, Lucia
dc.contributor.authorŞenkardeş, İsmail
dc.contributor.authorGevrenova, Reneta
dc.contributor.authorZheleva-Dimitrova, Dimitrina
dc.contributor.authorChiavaroli, Annalisa
dc.contributor.authorLeone, Sheila
dc.contributor.authorDi Simone, Simonetta
dc.contributor.authorBrunetti, Luigi
dc.contributor.authorPicot-Allain, Carene Marie Nancy
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorMenghini, Luigi
dc.date.accessioned2020-03-26T20:13:09Z
dc.date.available2020-03-26T20:13:09Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractEthyl acetate (EA), methanol (MeOH), and aqueous extracts of aerial parts of Anthemis tinctoria var. pallida (ATP) and A. cretica subsp. tenuiloba (ACT) were investigated for their phenol and flavonoid content, antioxidant, and key enzyme inhibitory potentials. All extracts displayed antiradical effects, with MeOH and aqueous extracts being a superior source of antioxidants. On the other hand, EA and MeOH extracts were potent against AChE and BChE. Enzyme inhibitory effects against tyrosinase and alpha-glucosidase were observed, as well. We also studied Anthemis extracts in an ex vivo experimental neurotoxicity paradigm. We assayed extract influence on oxidative stress and neurotransmission biomarkers, including lactate dehydrogenase (LDH) and serotonin (5-HT), in isolated rat cortex challenged with K+ 60 mM Krebs-Ringer buffer (excitotoxicity stimulus). An untargeted proteomic analysis was finally performed in order to explore the putative mechanism in the brain. The pharmacological study highlighted the capability of ACT water extract to blunt K+ 60 mM increase in LDH level and 5-HT turnover, and restore physiological activity of specific proteins involved in neuron morphology and neurotransmission, including NEFMs, VAMP-2, and PKC gamma, thus further supporting the neuroprotective role of ACT water extract.en_US
dc.description.sponsorshipItalian Ministry of UniversityMinistero dell' Istruzione, dell' Universita e della Ricerca (MIUR)en_US
dc.description.sponsorshipThis research was supported by Italian Ministry of University Grant (FAR 2017 granted to Claudio Ferrante; FAR 2017 granted to Giustino Orlando).en_US
dc.identifier.citationOrlando, G., Zengin, G., Ferrante, C., Ronci, M., Recinella, L., Şenkardeş, İ., Gevrenova, R., Zheleva-Dimitrova, D., Chiavaroli, A., Leone, S., Di Simone, S., Brunetti, L., Picot-Allain, C. M. N., Mahomoodally, M. F., Sinan, K. I., Menghini, L. (2019). Comprehensive Chemical Profiling and Multidirectional Biological Investigation of Two Wild Anthemis Species (Anthemis tinctoria var. Pallida and A. cretica subsp. tenuiloba): Focus on Neuroprotective Effects. Molecules, 24(14), 2582.
dc.identifier.doi10.3390/molecules24142582en_US
dc.identifier.issn1420-3049en_US
dc.identifier.issue14en_US
dc.identifier.pmid31315236en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.3390/molecules24142582
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37631
dc.identifier.volume24en_US
dc.identifier.wosWOS:000482303000065en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.institutionauthorSinan, Kouadio Ibrahime
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofMOLECULESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnthemisen_US
dc.subjectOxidative stressen_US
dc.subjectNeurotransmissionen_US
dc.subjectProteomicen_US
dc.subjectPhytomedicineen_US
dc.titleComprehensive Chemical Profiling and Multidirectional Biological Investigation of Two Wild Anthemis Species (Anthemis tinctoria var. Pallida and A. cretica subsp. tenuiloba): Focus on Neuroprotective Effectsen_US
dc.typeArticleen_US

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