Determination of operation time in colorectal diseases: Preoperative chemotherapy application

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dc.contributor.authorSahin, M
dc.contributor.authorErikoglu, M
dc.contributor.authorOzer, S
dc.contributor.authorTekin, A
dc.contributor.authorBoz, S
dc.contributor.authorGolcuk, M
dc.contributor.authorAvunduk, MC
dc.date.accessioned2020-03-26T16:56:49Z
dc.date.available2020-03-26T16:56:49Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground. Our aim was to determine the time it takes for wound healing to return to normal in cases where patients have undergone preoperative chemotherapy. Materials and methods. Eighty-four Wistar-albino rats were included in the study. Twelve of them were placed in the control group (Group 1), with no further drug administration. Another 12 rats were placed in a sham group (Group 11) and were peritoneally injected with 1 cc of isotonic saline solution 5 days a month, for a period of 6 months. The remaining 60 rats were placed in five chemotherapy groups (Groups III-VII) and were administered 20 mg/kg 5-fluorouracil through peritoneal injection, 5 days a month for a period of 6 months. At the end of the sixth cure, 12 rats from the control (Group 1), sham (Group II), and chemotherapy groups (Group III) were operated on, and an intestinal transsection. was applied to the rectosigmoid junction, followed by one-by-one anastomosis using 5/0 vicryl. Other groups (Groups IV-VI) with chemotherapy treatment were operated on at 1-week intervals and subjected to the same procedure. The subjects were reoperated on on the eleventh day. A full-layer 4 x 4 cm piece was removed from the abdominal wall containing the previous incision line at the middle, for tensile strength pressure measurements. In addition, a 4 cm colon segment was removed for bursting pressure measurements. Plasma albumin and tissue hydroxyproline levels were measured, and fibroblast numbers were counted in the sections prepared from the abdominal wall. Results. The control and sham groups were found to be similar to each other with respect to all parameters measured (P > 0.05). Significant reductions were observed in all parameters in the early chemotherapy groups compared with the control and sham groups (P <0.05). All parameters measured in Groups V, VI, and VII were found to be similar to those in the control and sham groups (P <0.05). Conclusion. Wound healing is impaired in rats with chemotherapy, but following the second week after the chemotherapy, disrupted parameters return to their normal levels. (C) 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2004.09.021en_US
dc.identifier.endpage215en_US
dc.identifier.issn0022-4804en_US
dc.identifier.issn1095-8673en_US
dc.identifier.issue2en_US
dc.identifier.pmid15820250en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage209en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jss.2004.09.021
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19658
dc.identifier.volume124en_US
dc.identifier.wosWOS:000228275800009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.relation.ispartofJOURNAL OF SURGICAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectprimary chemotherapyen_US
dc.subjectneoadjuvant chemotherapyen_US
dc.subjectbursting pressureen_US
dc.subjecttensile strength pressureen_US
dc.subjectfibroblastic activityen_US
dc.subjecttissue hydroxyprolineen_US
dc.subjectcolorectal canceren_US
dc.titleDetermination of operation time in colorectal diseases: Preoperative chemotherapy applicationen_US
dc.typeArticleen_US

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