Preventing Negative Effects of Smoking on Microarterial Anastomosis

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dc.contributor.authorTosun, Zekeriya
dc.contributor.authorKarabekmez, Furkan Erol
dc.contributor.authorDuymaz, Ahmet
dc.contributor.authorÖzkan, Adem
dc.contributor.authorKeskin, Mustafa
dc.contributor.authorAvunduk, Mustafa Cihat
dc.date.accessioned2020-03-26T18:04:51Z
dc.date.available2020-03-26T18:04:51Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAlthough microsurgery has rapid expanded, problems related to microarterial anastomosis continue. Cigarette smoking is one of the major risks for anastomosis by increasing platelet adhesion, and its effects on endothelial cells. Aim of this article is to study the negative effects of cigarettes on microarterial anastomosis line, and to investigate the protective effects of recombinant human erythropoietin (rHuEPO). Ninety-six Sprague-Dawley male rats were divided into 3 groups: group 1 was the control. Rats in groups 2 and 3 were exposed to cigarette smoke starting 21 days prior to surgery for 3 times a day. In group 3, additional 150 IU/kg rHuEPO was given via subcutaneously every 48 hours after microvascular anastomosis, femoral arterial samples, and blood samples were taken for assessment at 1st, 3rd, 5th, and 7th day. Intimae/media ratios were calculated for morphologic analyses. On morphologic analysis of femoral arteries there were statistically significant differences for all 3 groups at 1st, 3rd, 5th, and 7th days (P < 0, 05). The group that made differences was group 2, according to one-way analysis of variance within 3 groups in all days. Smoking decreases endothelial cells healing and causes more thromboses. rHuEPO can prevent these negative effects of smoking.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [2002-182]en_US
dc.description.sponsorshipSupported by Selcuk University Scientific Research Project Fund (Project No: 2002-182).en_US
dc.identifier.citationTosun, Z., Karabekmez, F. E., Duymaz, A., Özkan, A., Keskin, M., Avunduk, M. C., (2010). Preventing Negative Effects of Smoking on Microarterial Anastomosis. Annals of Plastic Surgery, 65(1), 91-95. Doi: 10.1097/SAP.0b013e3181b404fa
dc.identifier.doi10.1097/SAP.0b013e3181b404faen_US
dc.identifier.endpage95en_US
dc.identifier.issn0148-7043en_US
dc.identifier.issue1en_US
dc.identifier.pmid20548230en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage91en_US
dc.identifier.urihttps://dx.doi.org/10.1097/SAP.0b013e3181b404fa
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25182
dc.identifier.volume65en_US
dc.identifier.wosWOS:000279246300021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTosun, Zekeriya
dc.institutionauthorKarabekmez, Furkan Erol
dc.institutionauthorDuymaz, Ahmet
dc.institutionauthorKeskin, Mustafa
dc.institutionauthorAvunduk, Mustafa Cihat
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnnals of Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSmokingen_US
dc.subjectErythropoietinen_US
dc.subjectMicroarterial anastomosisen_US
dc.titlePreventing Negative Effects of Smoking on Microarterial Anastomosisen_US
dc.typeArticleen_US

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