EFFECT OF RECOMBINANT INTERLEUKIN-10 ON SOME HAEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN A RAT ENDOTOXAEMIC MODEL

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dc.contributor.authorCol, Ramazan
dc.contributor.authorDurgun, Zafer
dc.date.accessioned2020-03-26T18:14:17Z
dc.date.available2020-03-26T18:14:17Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractRecombinant interleukin-10 (rIL10) has been found to suppress the synthesis of tumour necrosis factor (TNF), interleukin-1 (IL-1), interleukin-6 (IL-6) and tissue factor and to improve survival from experimental sepsis. The aim of this study was to evaluate the protective effect of rIL-10 on lipopolysaccharide( LPS-) induced haematological and biochemical disturbances in rats. In the present study, 40 rats were used and divided equally into four groups. Group 1 (control group, C) was treated with 0.9% saline. Group 2: LPS was injected intravenously (1.6 mg/100 g), Group 3 received rIL10 treatment (125 mu g/kg) 2 min before 0.9% saline injection, Group 4 received rIL10 treatment 2 min before endotoxin treatment. When compared with the controls, platelet count, leukocyte count (with a marked neutrophilia and lymphopenia) and fibrinogen were decreased, while activated partial thromboplastin time (APTT) and prothrombin time (PT) were prolonged in the endotoxaemic rats. In addition, LPS caused statistically significant increases in plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities as well as creatinine, cholesterol and triglyceride concentrations, while it caused a statistically significant decrease in glucose, total protein and albumin levels as compared to the control group. On the other hand, rIL10 significantly suppressed disturbances in the haematological and biochemical parameters associated with endotoxaemia. As a result, rIL10 may be efficacious in preventing haematological disorders, tissue damage and changes in lipid, protein and carbohydrate metabolism in endotoxaemia.en_US
dc.description.sponsorshipBAP (Selcuk University, Konya, Turkey)Selcuk University [2003-101]en_US
dc.description.sponsorshipThis study was financed by BAP (2003-101, Selcuk University, Konya, Turkey).en_US
dc.identifier.doi10.1556/AVet.2011.009en_US
dc.identifier.endpage245en_US
dc.identifier.issn0236-6290en_US
dc.identifier.issue2en_US
dc.identifier.pmid21665577en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage237en_US
dc.identifier.urihttps://dx.doi.org/10.1556/AVet.2011.009
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26374
dc.identifier.volume59en_US
dc.identifier.wosWOS:000290433600009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAKADEMIAI KIADO RTen_US
dc.relation.ispartofACTA VETERINARIA HUNGARICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRecombinant interleukin-10en_US
dc.subjecthaematological and biochemical parametersen_US
dc.subjectendotoxinen_US
dc.subjectraten_US
dc.titleEFFECT OF RECOMBINANT INTERLEUKIN-10 ON SOME HAEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN A RAT ENDOTOXAEMIC MODELen_US
dc.typeArticleen_US

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