Sideritis galatica Bornm.: A source of multifunctional agents for the management of oxidative damage, Alzheimer's's and diabetes mellitus
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER SCIENCE BV
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The antioxidant and enzyme inhibitory potential of different solvent extracts (petroleum ether, ethyl acetate, methanol and water) from Sideritis galatica were evaluated. Cholinesterase, alpha-amylase and alpha-glucosidase inhibitory activities of the extracts were tested by microtiter plate assays. Antioxidant abilities were tested using free radical scavenging (DPPH (1,1-diphenyl-2-picrylhydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid) and NO), reducing power (FRAP (ferric reducing antioxidant power) and CUPRAC (cupric reducing antioxidant capacity)), total antioxidant capacity and chelating assays. Methanol and water extracts showed higher phenolic content, DPPH and ABTS scavenging activity and reducing power activities, while the petroleum ether and ethyl acetate extract had the highest inhibition abilities on the enzymes. 18 phenolic components in these extracts were detected by using high performance liquid chromatography-diode array detector (HPLC-DAD). Results obtained in this work indicate that S. galatica may be useful as a source of natural agents for the management of oxidative process, Alzheimer's disease and type II diabetes. (C) 2014 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Sideritis galatica, Antioxidant, Alzheimer's, Diabetes, HPLC
Kaynak
JOURNAL OF FUNCTIONAL FOODS
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
11
