Sideritis galatica Bornm.: A source of multifunctional agents for the management of oxidative damage, Alzheimer's's and diabetes mellitus

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorSarıkürkcü, Cengiz
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorCeylan, Ramazan
dc.date.accessioned2020-03-26T18:58:29Z
dc.date.available2020-03-26T18:58:29Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe antioxidant and enzyme inhibitory potential of different solvent extracts (petroleum ether, ethyl acetate, methanol and water) from Sideritis galatica were evaluated. Cholinesterase, alpha-amylase and alpha-glucosidase inhibitory activities of the extracts were tested by microtiter plate assays. Antioxidant abilities were tested using free radical scavenging (DPPH (1,1-diphenyl-2-picrylhydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid) and NO), reducing power (FRAP (ferric reducing antioxidant power) and CUPRAC (cupric reducing antioxidant capacity)), total antioxidant capacity and chelating assays. Methanol and water extracts showed higher phenolic content, DPPH and ABTS scavenging activity and reducing power activities, while the petroleum ether and ethyl acetate extract had the highest inhibition abilities on the enzymes. 18 phenolic components in these extracts were detected by using high performance liquid chromatography-diode array detector (HPLC-DAD). Results obtained in this work indicate that S. galatica may be useful as a source of natural agents for the management of oxidative process, Alzheimer's disease and type II diabetes. (C) 2014 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jff.2014.08.011en_US
dc.identifier.endpage547en_US
dc.identifier.issn1756-4646en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage538en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jff.2014.08.011
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31130
dc.identifier.volume11en_US
dc.identifier.wosWOS:000346885500054en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofJOURNAL OF FUNCTIONAL FOODSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSideritis galaticaen_US
dc.subjectAntioxidanten_US
dc.subjectAlzheimer'sen_US
dc.subjectDiabetesen_US
dc.subjectHPLCen_US
dc.titleSideritis galatica Bornm.: A source of multifunctional agents for the management of oxidative damage, Alzheimer's's and diabetes mellitusen_US
dc.typeArticleen_US

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