Serum neutrophil gelatinase-associated lipocalin is associated with cardiovascular events in patients with chronic kidney disease

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dc.contributor.authorSolak, Yalcin
dc.contributor.authorYilmaz, Mahmut Ilker
dc.contributor.authorSiriopol, Dimitrie
dc.contributor.authorSaglam, Mutlu
dc.contributor.authorUnal, Hilmi Umut
dc.contributor.authorYaman, Halil
dc.contributor.authorGok, Mahmut
dc.date.accessioned2020-03-26T19:07:04Z
dc.date.available2020-03-26T19:07:04Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin family best known as a novel and early marker of acute kidney injury (AKI). Recent data suggest that NGQueryAL is not only a marker of AKI, but also an important player in the vascular remodeling, atherosclerotic plaque stability and thrombus formation. We conducted this study to investigate the association of serum NGAL levels with fatal and composite (fatal and non-fatal) cardiovascular events (CVE) in a cohort of patients with stage 1-5 CKD. Methods This was an observational cohort study in which serum NGAL was obtained from 298 CKD (stages 1-5) patients. Fatal and composite CVE were recorded for a median 41 months. We examined alteration of serum NGAL through CKD groups as well as association with inflammatory markers. We also performed a Cox regression analysis to determine the association of NGAL with predefined clinical outcomes. Results The median value of NGAL was 50.5 ng/mL (IR 47.6-54.9 ng/mL), and higher NGAL values were recorded in diabetic patients. In a multiple linear regression model, including all univariate associates of NGAL, only log eGFR, log hs-CRP and log HDL cholesterol maintained an independent association with log NGAL. During the observational period, 30 patients died due to cardiovascular causes and 69 non-fatal CVE were registered. In the fully adjusted model, we observed a 2.08-fold increase in the risk of fatal CVE and a 1.50-fold increase in the risk of fatal and non-fatal CVE for each increment of 1 SD in log NGAL values. Conclusions This is the first study that shows that serum NGAL is associated with cardiovascular events (fatal and non-fatal) in patients with CKD, independently of traditional risk factors, renal function and inflammation.en_US
dc.description.sponsorshipUniversity of Medicine and Pharmacy, Iasi [1640/01.02.2013, IDEI-PCE 2011, PN-II-ID-PCE-2011-3-0637]en_US
dc.description.sponsorshipPart of this study was performed by grants number 1640/01.02.2013 and IDEI-PCE 2011, PN-II-ID-PCE-2011-3-0637 from the University of Medicine and Pharmacy, Iasi.en_US
dc.identifier.doi10.1007/s11255-015-1136-4en_US
dc.identifier.endpage2001en_US
dc.identifier.issn0301-1623en_US
dc.identifier.issn1573-2584en_US
dc.identifier.issue12en_US
dc.identifier.pmid26498629en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1993en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11255-015-1136-4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32545
dc.identifier.volume47en_US
dc.identifier.wosWOS:000369016000009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofINTERNATIONAL UROLOGY AND NEPHROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNGALen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectChronic kidney diseaseen_US
dc.subjectPredictionen_US
dc.subjectMortalityen_US
dc.titleSerum neutrophil gelatinase-associated lipocalin is associated with cardiovascular events in patients with chronic kidney diseaseen_US
dc.typeArticleen_US

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