In Vitro Anti-Helicobacter pylori Activity of Usnic Acid

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dc.contributor.authorŞafak, Birol
dc.contributor.authorÇiftci, İhsan Hakkı
dc.contributor.authorÖzdemir, Mehmet
dc.contributor.authorKıyıldı, Nilay
dc.contributor.authorÇetinkaya, Zafer
dc.contributor.authorAktepe, Orhan Cem
dc.contributor.authorAltındiş, Mustafa
dc.date.accessioned2020-03-26T17:38:56Z
dc.date.available2020-03-26T17:38:56Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractEradication of Helicobacter pylori is an important objective in overcoming gastric diseases. Many regimens are currently available but none of them could achieve 100% success in eradication. Medicinal lichen is used in the treatment of gastric ulcer in local folk medicine in Anatolia (Turkey). The present study was performed to assess the in vitro effects of usnic acid from Usnea dasypoga against clinical isolates and standard H. pylori strains and their minimum inhibitory concentrations (MICs). A total of 38 strains was assayed for anti-H. pylori activity. The agar dilution method was used for the determination of usnic acid and clarithromycin resistance. Six (16.2%) clinical isolates were resistant to usnic acid and five (13.5%) were resistant to clarithromycin. Dual susceptibility to usnic acid and clarithromycin rate was detected as very high (97.3%). Usnic acid has a strong and dose-dependent activity against H. pylori strains. The synergism between usnic acid and clarithromycin may be effective in the treatment of H. pylori infection. Copyright (C) 2009 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/ptr.2690en_US
dc.identifier.endpage957en_US
dc.identifier.issn0951-418Xen_US
dc.identifier.issn1099-1573en_US
dc.identifier.issue7en_US
dc.identifier.pmid19367654en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage955en_US
dc.identifier.urihttps://dx.doi.org/10.1002/ptr.2690
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23607
dc.identifier.volume23en_US
dc.identifier.wosWOS:000268304700011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofPHYTOTHERAPY RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHelicobacter pylorien_US
dc.subjectusnic aciden_US
dc.subjectclarithromycinen_US
dc.titleIn Vitro Anti-Helicobacter pylori Activity of Usnic Aciden_US
dc.typeArticleen_US

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