Homocysteine levels and total antioxidant capacity in children with acute rheumatic fever

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dc.contributor.authorKurban, Sevil
dc.contributor.authorMehmetoglu, Idris
dc.contributor.authorOran, Bulent
dc.contributor.authorKiyici, Aysel
dc.date.accessioned2020-03-26T17:27:00Z
dc.date.available2020-03-26T17:27:00Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The aim of the study was to investigate total antioxidant capacity (TAC) and homocysteine levels in children with acute rheumatic fever (ARF). Design and methods: Nineteen patients with ARE and twenty healthy children, age- and sex-matched were included in the study. Follow-up studies were made at the 7(th), 14(th), 21(st) and 28(th) day of diagnosis. Results: Children with ARF had significantly higher serum homocysteine levels and lower TAC than the same parameters of the controls at all measurements. Following the anti-inflammatory therapy, we found a progressive increase in TAC and a decrease in homocysteine levels of the patients. Conclusion: We concluded that increased serum homocysteine levels and decreased serum TAC of the patients with ARF can be considered as a sign of increased inflammation and oxidative stress in these patients which needs to be considered during therapy. Further studies are needed to understand the underlying mechanisms of these findings. (c) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.clinbiochem.2007.09.015en_US
dc.identifier.endpage29en_US
dc.identifier.issn0009-9120en_US
dc.identifier.issue01.02.2020en_US
dc.identifier.pmid17964295en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage26en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.clinbiochem.2007.09.015
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22443
dc.identifier.volume41en_US
dc.identifier.wosWOS:000251854800004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofCLINICAL BIOCHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectacute rheumatic feveren_US
dc.subjecthomocysteineen_US
dc.subjecttotal antioxidant capacityen_US
dc.subjectchildrenen_US
dc.titleHomocysteine levels and total antioxidant capacity in children with acute rheumatic feveren_US
dc.typeArticleen_US

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