Preventive Role of Magnesium on Skeletal Muscle Ischemia-Reperfusion Injury-an Experimental Study

Basit Öğe Kaydı
dc.contributor.authorGörmüş, Zülfikare Işık
dc.contributor.authorErgene, Neyhan
dc.contributor.authorToy, Hatice
dc.contributor.authorBaltacı, Abdülkerim Kasım
dc.contributor.authorMoğulkoç, Rasim
dc.date.accessioned2020-03-26T17:39:47Z
dc.date.available2020-03-26T17:39:47Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe present study aims to explore whether Mg infusion has a preventive effect on ischemia-reperfusion injury in rats. A total of 20 Sprague-Dawley-type adult male rats were used. In group 1 (control), 0.9% isotonic solution was administered. In group 2 (experiment), magnesium sulfate (0.5 mg per 100 g) was administered. Ischemia was induced for 15 min for the two groups. Magnesium (Mg), interleukin 8 (IL-8), and malondialdehyde levels were analyzed in blood, while edema, neutrophil infiltration, eosinophilia, loss of striation, and nucleolization were evaluated in histopathological examination. Mg levels in the experiment group were higher than those in the control group after ischemia-reperfusion (p < 0.05). In the control group, postischemia and postreperfusion IL-8 values were higher than preoperative values (p < 0.05). As for eosinophilia and loss of striation values, these were higher in the experiment group after ischemia-reperfusion than the values in the control group (p < 0.05). Histopathologically, Mg infusion cannot prevent the tissue injury triggered in ischemia-reperfusion periods. Eosinophilia can be one of the major and earliest markers of ischemia-reperfusion injury.en_US
dc.identifier.doi10.1007/s12011-008-8228-2en_US
dc.identifier.endpage189en_US
dc.identifier.issn0163-4984en_US
dc.identifier.issn1559-0720en_US
dc.identifier.issue2en_US
dc.identifier.pmid18806932en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s12011-008-8228-2
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23787
dc.identifier.volume127en_US
dc.identifier.wosWOS:000262432700012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHUMANA PRESS INCen_US
dc.relation.ispartofBIOLOGICAL TRACE ELEMENT RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMagnesiumen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectInterleukin 8 (IL-8)en_US
dc.subjectMalondialdehyde (MDA)en_US
dc.titlePreventive Role of Magnesium on Skeletal Muscle Ischemia-Reperfusion Injury-an Experimental Studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu