Plasma concentrations of soluble CD40 ligand in smokers with acute myocardial infarction: a pilot study

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dc.contributor.authorKayrak, Mehmet
dc.contributor.authorBacaksiz, Ahmet
dc.contributor.authorUlgen, Mehmet S.
dc.contributor.authorVatankulu, Mehmet Akif
dc.contributor.authorZengin, Kadriye
dc.contributor.authorAyhan, Selim S.
dc.contributor.authorBasarali, Mustafa Kemal
dc.date.accessioned2020-03-26T18:15:38Z
dc.date.available2020-03-26T18:15:38Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCoronary artery disease (CAD) is believed to be the single leading cause of death in both men and women in the world. Smoking is the most important risk factor for CAD. Smoking increases platelet aggregation and thrombus formation. CD40 ligand (CD40L) is a transmembrane glycoprotein derived from activated platelets. It participates in thrombus formation during the acute phase of acute myocardial infarction (MI). Elevation of CD40L identifies the patients who are at highest risk for cardiac events and who are likely to benefit from treatment with the glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonists. The purpose of this study was to evaluate levels of CD40L in smokers with acute MI. Fifty-seven patients with acute MI were enrolled in this study. Thirty-one smokers were compared with 26 non-smokers. Soluble CD40L level in the plasma was determined by a standard enzyme-linked immunosorbent assay. Circulating levels of CD40L were higher in the smokers' group. Smokers with acute MI may have increased risk for thrombotic complications during acute MI, and optimal antiaggregant therapy should be administered.en_US
dc.identifier.doi10.1007/s00380-010-0036-xen_US
dc.identifier.endpage137en_US
dc.identifier.issn0910-8327en_US
dc.identifier.issn1615-2573en_US
dc.identifier.issue2en_US
dc.identifier.pmid20978895en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage131en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00380-010-0036-x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26720
dc.identifier.volume26en_US
dc.identifier.wosWOS:000288259700002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofHEART AND VESSELSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAcute myocardial infarctionen_US
dc.subjectCD40 liganden_US
dc.subjectSmokingen_US
dc.titlePlasma concentrations of soluble CD40 ligand in smokers with acute myocardial infarction: a pilot studyen_US
dc.typeArticleen_US

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