Chemical and biological insights on Cotoneaster integerrimus: A new (-)- epicatechin source for food and medicinal applications

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dc.contributor.authorUysal, Ahmet
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMollica, Adriano
dc.contributor.authorGüneş, Erdoğan
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorYılmaz, Turgut
dc.contributor.authorAktümsek, Abdurrahman
dc.date.accessioned2020-03-26T19:23:18Z
dc.date.available2020-03-26T19:23:18Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The Cotoneaster species are widely used as traditional purposes in different countries including Turkey. Purpose: The study was performed to evaluate the biological and chemical profile of two extracts (methanol (T-Me; F-Me) and water (T-W; F-W)) from two parts (twigs and fruits) of Cotoneaster integerrimus. Materials and methods: Antioxidant (free radical scavenging (DPPH), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating), enzyme inhibitory (cholinesterase, tyrosinase, alpha-amylase and alpha-glucosidase), antimicrobial (standard microorganisms and methicillin-resistant Staphylococcus aureus isolates (MRSA)) and mutagenic/antimutagenic effects (by Ames assay) were tested for biological profile. For chemical profile, total and individual phenolic components were detected for each extract. Results: Generally, T-Me reflected the strongest biological effects with the highest level of phenolics (115. 15 mgGAEs/g extract). Also, twig extracts had more potent biological effects as compared to flower extracts. Eight-teen phenolics were identified in the extracts. (-)- epicatechin was the major constituent in all extracts and is mainly responsible for biological activities observed. Its amount present in F-W and T-W were 9.27 and 32.89 mg/g extract, respectively. Also, molecular docking was used to understand enzyme-epicatechin interactions. Conclusion: From these results, this plant has a great potential as a health promoter for developing novel functional food ingredients and pharmaceutical preparations. (C) 2016 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.phymed.2016.06.011en_US
dc.identifier.endpage988en_US
dc.identifier.issn0944-7113en_US
dc.identifier.issue10en_US
dc.identifier.pmid27444342en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage979en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.phymed.2016.06.011
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33347
dc.identifier.volume23en_US
dc.identifier.wosWOS:000379834500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER GMBH, URBAN & FISCHER VERLAGen_US
dc.relation.ispartofPHYTOMEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCotoneasteren_US
dc.subject(-)-epicatechinen_US
dc.subjectBiological effecten_US
dc.subjectChemical fingerprinten_US
dc.subjectMolecular dockingen_US
dc.subjectNutraceuticalsen_US
dc.titleChemical and biological insights on Cotoneaster integerrimus: A new (-)- epicatechin source for food and medicinal applicationsen_US
dc.typeArticleen_US

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