Effect of inflammatory marker activity after intra-articular injection of autologous platelet-rich plasma in dogs with osteoarthritis

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dc.contributor.authorArıcan, Mustafa.
dc.contributor.authorŞimşek, Atilla.
dc.contributor.authorParlak, Kurtuluş.
dc.contributor.authorAtlı, Kamil.
dc.contributor.authorSönmez, Gonca.
dc.date.accessioned2020-03-26T20:13:39Z
dc.date.available2020-03-26T20:13:39Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümüen_US
dc.description.abstractOsteoarthritis (OA) is a common cause of lameness, pain, and dysfunction in dogs. To determine the levels of interleukin (IL) (IL-1 beta, IL-6, IL-10), tumor necrosis factor (TNF)-alpha, and prostaglandin E-2 (PG-E-2) in the synovial fluid after intra-articular injection of an autologous platelet-rich plasma concentrate to treat dogs with osteoarthritis. Twenty dogs with osteoarthritis (OA) were used as a materials. Fourteen dogs were used as a platelet-rich plasma (PRP) treatment group and 6 dogs were used as a control (0.9% NaCl). PRP was obtained by the double centrifuge method. Affected joints were examined by radiography and ultrasonography. Lameness and pain severity were evaluated by attending clinicians. Samples were collected under sterile conditions at pre-treatment, days 1, 3, 5, 7, 15, and weeks 4, 8, and 12. The marker levels were determined by an enzyme-linked immunosorbent assay. No adverse effects of the injection of platelet concentrate or saline solution were observed. No significant differences were found in the Hudson Visual Analog Scale and Canine Brief Pain Inventory scores between weeks 0, 4, and 12 in the control dogs. No significant changes were observed in IL-1 beta, IL-6, IL-10, TNF-alpha, and PG-E-2 levels (P > 0.05) in synovial fluid from the PRP treatment group compared to synovial fluid from the control group, although fluctuations in parameter levels were observed in both groups. Despite some variable results in inflammatory parameters, clinical improvement was recorded in the PRP-treated group. PRP injection could be an effective and safe method for treatment of dogs with osteoarthritis.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [213O175]en_US
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK, Project no. 213O175).en_US
dc.identifier.citationArıcan, M., Şimşek, A., Parlak, K., Atlı, K., Sönmez, G. (2019). Effect of Inflammatory Marker Activity After Intra-Articular Injection of Autologous Platelet-Rich Plasma in Dogs with Osteoarthritis. Medycyna Weterynaryjna, 75(12), 744-748.
dc.identifier.doi10.21521/mw.6285en_US
dc.identifier.endpage748en_US
dc.identifier.issn0025-8628en_US
dc.identifier.issue12en_US
dc.identifier.startpage744en_US
dc.identifier.urihttps://dx.doi.org/10.21521/mw.6285
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37736
dc.identifier.volume75en_US
dc.identifier.wosWOS:000503037900009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorArıcan, Mustafa.
dc.institutionauthorŞimşek, Atilla.
dc.institutionauthorParlak, Kurtuluş.
dc.institutionauthorAtlı, Kamil.
dc.institutionauthorSönmez, Gonca.
dc.language.isoenen_US
dc.publisherPOLISH SOC VETERINARY SCIENCES EDITORIAL OFFICEen_US
dc.relation.ispartofMEDYCYNA WETERYNARYJNA-VETERINARY MEDICINE-SCIENCE AND PRACTICEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcytokinesen_US
dc.subjectIL-1 betaen_US
dc.subjectIL-6en_US
dc.subjectIL-10en_US
dc.subjectTNF-alphaen_US
dc.subjectPG-E-2en_US
dc.subjectanti-inflammatory effecten_US
dc.titleEffect of inflammatory marker activity after intra-articular injection of autologous platelet-rich plasma in dogs with osteoarthritisen_US
dc.typeArticleen_US

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