Effect of zinc supplementation on lipid peroxidation and lactate levels in rats with diabetes induced by streptozotocin and subjected to acute swimming exercise

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dc.contributor.authorBicer, M.
dc.contributor.authorGunay, M.
dc.contributor.authorBaltaci, A. K.
dc.contributor.authorUney, K.
dc.contributor.authorMogulkoc, R.
dc.contributor.authorAkil, M.
dc.date.accessioned2020-03-26T18:25:07Z
dc.date.available2020-03-26T18:25:07Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The present study aims to explore the effect of zinc supplementation on lipid peroxidation and lactate levels in rats having diabetes induced by streptozotocin and subjected to acute swimming exercise Method: A total of 80 adult male rats of Sprague-Dawley type were equally allocated to 8 groups: Group 1, general control. Group 2, zinc-supplemented group. Group 3, zinc-supplemented, diabetic group. Group 4, swimming control group. Group 5, zinc-supplemented swimming group. Group 6, zinc-supplemented diabetic swimming group. Group 7, diabetic swimming group. Group 8, diabetic group. At the end of the 4-week study, blood samples were collected to determine MDA, GSH, GPx, SOD, lactate and zinc levels. Results: The highest MDA values were found in group 7 and 8 (p<0.001). GSH values in groups 5 and 6 were higher (p<0.001). The highest GPx values were established in groups 2, 5 and 6 (p<0.001). SOD values were the highest in groups 5 and 6 (p<0.001) and lowest in groups 2, 3 and 8 (p<0.001). The highest plasma lactate levels were found in group 7 (p<0.001). The highest zinc levels were obtained in groups 1,2 and 5 (p<0.001), and the lowest zinc levels were found in groups 7 and 8 (p<0.001). Conclusion: Results of the study reveal that zinc supplementation prevents the increase in free radical formation, suppression of antioxidant activity and muscle exhaustion, all of which result from diabetes and acute exercise. Zinc supplementation may contribute to health and performance in diabetes and acute exercise (Tab. 2, Fig. 1 Ref. 47). Full Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2012_046en_US
dc.identifier.endpage205en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue4en_US
dc.identifier.pmid22502748en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage199en_US
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2012_046
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27960
dc.identifier.volume113en_US
dc.identifier.wosWOS:000303372800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectzincen_US
dc.subjectdiabetesen_US
dc.subjectexerciseen_US
dc.subjectfree radicalsen_US
dc.subjectraten_US
dc.titleEffect of zinc supplementation on lipid peroxidation and lactate levels in rats with diabetes induced by streptozotocin and subjected to acute swimming exerciseen_US
dc.typeArticleen_US

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