Curcumin Modulates Muscle Damage but not Oxidative Stress and Antioxidant Defense Following Eccentric Exercise in Rats

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dc.contributor.authorBoz, Ismail
dc.contributor.authorBelviranli, Muaz
dc.contributor.authorOkudan, Nilsel
dc.date.accessioned2020-03-26T18:49:56Z
dc.date.available2020-03-26T18:49:56Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: The purpose of this study was to investigate the effects of curcumin on eccentric exercise-induced muscle damage and oxidative stress in rats. Methods: Thirty male Wistar rats were divided into four groups: Control (C; no curcumin, no exercise; n=6), Curcumin (Cur; n=8), Exercise (E; n=8) and Exercise Plus Curcumin (ECur; n=8). Curcumin was given for 20 days via oral gavage at doses of 200 mg/kg(-1) of body weight per day, dissolved in corn oil. On the 21st day eccentric exercise was provided via a treadmill run and the rats were sacrificed immediately after. Results: Eccentric exercise resulted in significant (p < 0.05) increases in all injury markers such as creatine kinase (CK) and myoglobin, but curcumin supplementation tended to decrease CK activity (p > 0.05) and significantly decreased myoglobin levels (p < 0.05). In blood and muscle samples, malondialdehyde (MDA) levels were not affected by either curcumin or exercise (p > 0.05). MDA levels in liver tissue decreased in the ECur group, compared to the control (p < 0.05). Superoxide dismutase (SOD) activities and glutathione (GSH) levels were affected by neither curcumin nor exercise (p > 0.05), in blood, muscle and liver tissues. Conclusion: The results of this study suggest that curcumin has a protective effect on eccentric exercise induced muscle damage, and that this effect might be independent of oxidative stress and antioxidant systems.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [SABE 11202040]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research and Project Coordinator of Selcuk University (Grant no. SABE 11202040).en_US
dc.identifier.doi10.1024/0300-9831/a000203en_US
dc.identifier.endpage172en_US
dc.identifier.issn0300-9831en_US
dc.identifier.issn1664-2821en_US
dc.identifier.issue03.04.2020en_US
dc.identifier.pmid26098480en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage163en_US
dc.identifier.urihttps://dx.doi.org/10.1024/0300-9831/a000203
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30714
dc.identifier.volume84en_US
dc.identifier.wosWOS:000355715500006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVERLAG HANS HUBERen_US
dc.relation.ispartofINTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcurcuminen_US
dc.subjectmuscle damageen_US
dc.subjectexerciseen_US
dc.subjectoxidative stressen_US
dc.titleCurcumin Modulates Muscle Damage but not Oxidative Stress and Antioxidant Defense Following Eccentric Exercise in Ratsen_US
dc.typeArticleen_US

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