Impact of neoadjuvant chemotherapy on short-term complications and survival following radical cystectomy

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dc.contributor.authorMilenkovic, Uros
dc.contributor.authorAkand, Murat
dc.contributor.authorMoris, Lisa
dc.contributor.authorDemaegd, Liesbeth
dc.contributor.authorMuilwijk, Tim
dc.contributor.authorBekhuis, Youri
dc.contributor.authorLaenen, Annouschka
dc.contributor.authorCleynenbreugel, Ben Van
dc.contributor.authorEveraerts, Wouter
dc.contributor.authorPoppel, Hein Van
dc.contributor.authorDumez, Herlinde
dc.contributor.authorAlbersen, Maarten
dc.contributor.authorJoniau, Steven
dc.date.accessioned2020-03-26T20:14:37Z
dc.date.available2020-03-26T20:14:37Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives To compare perioperative and short-term postoperative complication rates between patients receiving radical cystectomy (RC) after neoadjuvant chemotherapy (NAC) and patients undergoing RC alone. Secondary objectives were to compare overall survival (OS) and cancer-specific survival (CSS). Materials and methods Clinico-pathological data of all patients who received RC between 1996 and 2015 were retrospectively collected. Only patients with RC for muscle-invasive bladder cancer were included in the final analysis. Short-term (30-day) postoperative complications were assessed by registering the Clavien-Dindo classification (CDC) and dividing into sub-groups: low-grade (LGC) CDC 1-2 and high-grade (HGC) CDC 3-5. To compare populations with similar age, comorbidities and preoperative creatinine, we used a propensity score-adjusted statistical model. Pre- and perioperative predictors of short-term complications were identified using uni- and multivariable models. Survival was assessed using Kaplan-Meier analysis. Results A total of 491 patients undergoing RC were included, of whom 102 (20.8%) received NAC. After propensity score covariate adjustment, there was no significant difference in postoperative complications between patients undergoing NAC plus RC and RC alone with an overall complication rate of 69% and 66%, respectively. No significant differences in the 30-day HGC rates (11.76% and 11.83%, respectively) were observed. NAC plus RC patients had worse prognostic factors at baseline; nevertheless, after correction for group differences OS and CSS did not differ from RC only group (5-year OS 61.3% vs. 50.2%, and 5-year CSS 61.8% vs. 57.9% respectively, p > 0.05 for all). Conclusion In appropriately selected patients, exposure to NAC is not associated with increased short-term complications.en_US
dc.description.sponsorshipEuropean Urologic Scholarship Program (EUSP)en_US
dc.description.sponsorshipAkand M is supported by a clinical scholarship from the European Urologic Scholarship Program (EUSP).Joniau S is a senior clinical researcher of the research foundation of Flanders (FWO).en_US
dc.identifier.citationMilenkovic, U., Akand, M., Moris, L., Demaegd, L., Muilwijk, T., Bekhuis, Y., Laenen, A., Cleynenbreugel, B. V., Everaerts, W., Poppel, H. V., Dumez, H., Albersen, M., Joniau, S. (2019). Impact Of Neoadjuvant Chemotherapy On Short-Term Complications And Survival Following Radical Cystectomy. World Journal Of Urology, 37,(9), 1857-1866.
dc.identifier.doi10.1007/s00345-018-2584-0en_US
dc.identifier.endpage1866en_US
dc.identifier.issn0724-4983en_US
dc.identifier.issn1433-8726en_US
dc.identifier.issue9en_US
dc.identifier.pmid30519746en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1857en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00345-018-2584-0
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37907
dc.identifier.volume37en_US
dc.identifier.wosWOS:000483691700014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAkand, Murat
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofWORLD JOURNAL OF UROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRadical cystectomyen_US
dc.subjectBladder canceren_US
dc.subjectNeoadjuvant chemotherapyen_US
dc.subjectComplicationsen_US
dc.subjectShort termen_US
dc.titleImpact of neoadjuvant chemotherapy on short-term complications and survival following radical cystectomyen_US
dc.typeArticleen_US

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