Morphological Versatility in the Self-Assembly of Val-Ala and Ala-Val Dipeptides

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dc.contributor.authorErdogan, Hakan
dc.contributor.authorBabur, Esra
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorCandas, Elif
dc.contributor.authorGordesel, Merve
dc.contributor.authorDede, Yavuz
dc.contributor.authorOren, Ersin Emre
dc.date.accessioned2020-03-26T19:06:23Z
dc.date.available2020-03-26T19:06:23Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractSince the discovery of dipeptide self-assembly, diphenylalanine (Phe-Phe)-based dipeptides have been widely investigated in a variety of fields. Although various supramolecular Phe-Phe-based structures including tubes, vesicles, fibrils, sheets, necklaces, flakes, ribbons, and wires have been demonstrated by manipulating the external physical or chemical conditions applied, studies of the morphological diversity of dipeptides other than Phe-Phe are still required to understand both how these small molecules respond to external conditions such as the type of solvent and how the peptide sequence affects self-assembly and the corresponding molecular structures. In this work, we investigated the self-assembly of valine-alanine (Val-Ala) and alanine-valine (Ala-Val) dipeptides by varying the solvent medium. It was observed that Val-Ala dipeptide molecules may generate unique self-assembly-based morphologies in response to the solvent medium used. Interestingly, when Ala-Val dipeptides were utilized as a peptide source instead of Val-Ala, we observed distinct differences in the final dipeptide structures. We believe that such manipulation may not only provide us with a better understanding of the fundamentals of the dipeptide self-assembly process but also may enable us to generate novel peptide-based materials for various applications.en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [111M237]; Turkish Academy of Sciences Distinguished Young Scientist Award (TUBA-GEBIP)Turkish Academy of Sciencesen_US
dc.description.sponsorshipThis work was supported by TUBITAK (grant no. 111M237). G.D. and E.E.O. also acknowledge support from the Turkish Academy of Sciences Distinguished Young Scientist Award (TUBA-GEBIP).en_US
dc.identifier.doi10.1021/acs.langmuir.5b01406en_US
dc.identifier.endpage7345en_US
dc.identifier.issn0743-7463en_US
dc.identifier.issue26en_US
dc.identifier.pmid26086903en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage7337en_US
dc.identifier.urihttps://dx.doi.org/10.1021/acs.langmuir.5b01406
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32341
dc.identifier.volume31en_US
dc.identifier.wosWOS:000357839200020en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.relation.ispartofLANGMUIRen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleMorphological Versatility in the Self-Assembly of Val-Ala and Ala-Val Dipeptidesen_US
dc.typeArticleen_US

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