Association Between the T-593A and C6982T Polymorphisms of the Osteopontin Gene and Risk of Developing Nephrolithiasis

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dc.contributor.authorGöğebakan, Bülent
dc.contributor.authorİğci, Yusuf Ziya
dc.contributor.authorArslan, Ahmet
dc.contributor.authorİğci, Mehri
dc.contributor.authorErturhan, Sakip
dc.contributor.authorÖztuzcu, Serdar
dc.contributor.authorŞen, Haluk
dc.contributor.authorDemiryürek, Seniz
dc.contributor.authorArıkoğlu, Hilal
dc.contributor.authorCengiz, Beyhan
dc.contributor.authorBayraktar, Recep
dc.contributor.authorYurtseven, Cihanser
dc.contributor.authorSarıca, Kemal
dc.contributor.authorDemiryürek, Abdullah T.
dc.date.accessioned2020-03-26T17:47:09Z
dc.date.available2020-03-26T17:47:09Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and Aims. Increased synthesis of several urinary proteins including osteopontin (OPN) has been shown to be associated with stone formation within the urinary tract. The objective of this study was to analyze the genotype distributions and allele frequencies for OPN gene promoter T-593A and C6982T (in exon 7) polymorphisms among patients with kidney stones. Methods. In this case-control study, the study group consisted of 121 patients with radiologically confirmed nephrolithiasis. Genomic DNA from patients and control cases (n = 100) was analyzed by single-strand conformation polymorphism method and nucleotide sequence analysis. Results. Homozygous carriers of the T-593T genotype were more frequent, but carriers of the A-593A genotype were less frequent in patients than in controls. There was also an increase in -593T allele (88% in patients vs. 79% in controls) and decrease in -593A allele frequencies (21% in control vs. 12% in patients) in the nephrolithiasis groups (p = 0.013). The carriers of C6982C genotype were less frequent, but marked increases in T6982T genotype (25.6% in patients vs. 7% in controls, p = 0.001) and 6982T allele frequency (53.3% in patients vs. 37.5% in controls, p = 0.001) were noted in patients of Turkish ancestry. Conclusions. These results are the first to demonstrate the existence of T-593A promoter polymorphism of the OPN gene and significant association with risk of developing nephrolithiasis. Our results showed marked associations between polymorphisms (C6982T and T-593A) of the OPN gene and the stone-forming phenotypes in the Turkish population.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [SBAG-2786, 104S370]en_US
dc.description.sponsorshipThis study was supported by a research project (SBAG-2786, 104S370) from The Scientific and Technological Research Council of Turkey (TUBITAK).en_US
dc.identifier.citationGöğebakan, B., İğci, Y. Z., Arslan, A., İğci, M., Erturhan, S., Öztuzcu, S., Şen, H., Demiryürek, S., Arıkoğlu, H., Cengiz, B., Bayraktar, R., Yurtseven, C., Sarıca, K., Demiryürek, A. T., (2010). Association Between the T-593A and C6982T Polymorphisms of the Osteopontin Gene and Risk of Developing Nephrolithiasis. Archives of Medical Research, (41), 442-448. Doi: 10.1016/j.arcmed.2010.08.014
dc.identifier.doi10.1016/j.arcmed.2010.08.014en_US
dc.identifier.endpage448en_US
dc.identifier.issn0188-4409en_US
dc.identifier.issue6en_US
dc.identifier.pmid21044748en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage442en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.arcmed.2010.08.014
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24635
dc.identifier.volume41en_US
dc.identifier.wosWOS:000284678700007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorArıkoğlu, Hilal
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofArchives of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectKidney stoneen_US
dc.subjectOsteopontinen_US
dc.subjectPolymorphismsen_US
dc.subjectNephrolithiasisen_US
dc.subjectHaplotypesen_US
dc.titleAssociation Between the T-593A and C6982T Polymorphisms of the Osteopontin Gene and Risk of Developing Nephrolithiasisen_US
dc.typeArticleen_US

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