The effects of isotretinoin therapy on the biliary system

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dc.authorid0000-0002-3106-4280
dc.authorid0000-0002-9339-8331
dc.contributor.authorSaylam Kurtipek, Gülcan
dc.contributor.authorUlutaşDemirbaş, Gözde
dc.contributor.authorDemirbaş, Abdullah
dc.contributor.authorSarı, Nihal
dc.contributor.authorZekey, Emre
dc.contributor.authorTuncez Akyürek, Fatma
dc.contributor.authorGüngör, Gökhan
dc.date.accessioned2020-03-26T20:20:33Z
dc.date.available2020-03-26T20:20:33Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of the present study was to investigate the potential effects of isotretinoin on the biliary system in patients with acne vulgaris receiving isotretinoin therapy. This was a preliminary retrospective study involving 40 patients with severe acne vulgaris who attended the dermatology clinic and were administered different doses (20 or 30 mg/day) of isotretinoin. Serum levels of AST, ALT, ALP, GGT, total bilirubin, direct bilirubin, and indirect bilirubin at the beginning and at the first month of therapy were scanned, recorded, and statistically analyzed. Total and indirect bilirubin levels at the first month of treatment in 30 patients, receiving isotretinoin at a dose of 20 mg/day, were significantly lower compared to the baseline values (p = .02 and p = .03, respectively), whereas AST and GGT serum levels were significantly higher (p = .003 and p = .006 respectively). No significant reduction in total and indirect bilirubin levels was detectable at the first month of treatment in 10 patients receiving isotretinoin at a dose of 30 mg/day; however, AST, ALP, and GGT levels were significantly elevated in these patients (p = .023; p = .004; and p = .001, respectively). To our knowledge, there is no previous study investigating the effects of isotretinoin on the biliary system, and, therefore, the present study is a preliminary one. Our findings implicate that low dose (20 mg/day) isotretinoin therapy can potentially reduce total and indirect bilirubin levels. Long-term, large-scale, prospective studies with patients receiving different doses of isotretinoin may provide more reliable information regarding the bilirubin lowering effects of isotretinoin and optimum dosing for achieving this clinical effect.en_US
dc.identifier.citationKurtipek, G. S., Demirbas, G. U., Demirbas, A., Sarı, N., Zekey, E., Akyurek, F. T., Güngör, G. (2020). The Effects of Isotretinoin Therapy on the Biliary System. Dermatologic Therapy, 33(1), 1-4.
dc.identifier.doi10.1111/dth.13177en_US
dc.identifier.issn1396-0296en_US
dc.identifier.issn1529-8019en_US
dc.identifier.issue1en_US
dc.identifier.pmid31769896en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1111/dth.13177
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38615
dc.identifier.volume33en_US
dc.identifier.wosWOS:000501595400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSaylam Kurtipek, Gulcan
dc.institutionauthorUlutas Demirbas, Gözde
dc.institutionauthorDemirbas, Abdullah
dc.institutionauthorSarı, Nihal
dc.institutionauthorZekey, Emre
dc.institutionauthorTuncez Akyurek, Fatma
dc.institutionauthorGüngör, Gökhan
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofDERMATOLOGIC THERAPYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectacneen_US
dc.subjectbilirubinen_US
dc.subjectisotretinoinen_US
dc.titleThe effects of isotretinoin therapy on the biliary systemen_US
dc.typeArticleen_US

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