Short-Term Effects of Ankaferd Hemostat for Renal Artery Embolization: An Experimental Study

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dc.contributor.authorOzbek, Orhan
dc.contributor.authorAcar, Kadir
dc.contributor.authorKoc, Osman
dc.contributor.authorSaritas, Kadir
dc.contributor.authorToy, Hatice
dc.contributor.authorSolak, Yalcin
dc.contributor.authorOzbek, Seda
dc.date.accessioned2020-03-26T18:43:21Z
dc.date.available2020-03-26T18:43:21Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractRenal artery embolization (RAE) is a minimally invasive therapeutic technique that is utilized in a number of disorders. Ankaferd is a novel hemostatic agent with a new mechanism of action independent of clotting factors. We used Ankaferd for RAE in a sheep model. Seven adult female sheep were included in the study. Selective renal arteriogram using 5-F diagnostic catheter was performed to make sure that each kidney was fed by a single renal artery and the animal had normal renal vasculature. Coaxial 2.7-F microcatheter was advanced to the distal main renal artery. Under fluoroscopic guidance, 2 mL of Ankaferd mixed with 2 mL of nonionic iodinated contrast agent was slowly injected. Fluoroscopy was used to observe the deceleration of flow and stagnation. Control renal angiograms were performed just after embolization. After the procedure, the animals were observed for 1 day and then sacrificed with intravenous sodium thiopental. The technical success was observed in seven of the seven animals.. After embolization procedure, none of the animals died or experienced a major systemic adverse event. On macroscopic examination of the embolized kidneys, thrombus at the level of main renal artery formed after Ankaferd embolization was more compact compared with the thrombi that was not Ankaferd-associated, which was observed elsewhere. Microscopically, majority of the renal tubular cells (80-90 %) were necrotic, and there was epithelial cell damage in a small portion of the cells (10-20 %). RAE was safe and effective in the short-term with Ankaferd in studied animals. Further studies should be conducted to better delineate the embolizing potential of this novel hemostatic agent.en_US
dc.description.sponsorshipGenc Medical; ERA-EDTAen_US
dc.description.sponsorshipThe authors thank Genc Medical for financial support for the conduction of the study. Dr. A. Gaipov received grant support from the ERA-EDTA fellowship program.en_US
dc.identifier.doi10.1007/s00270-012-0419-8en_US
dc.identifier.endpage504en_US
dc.identifier.issn0174-1551en_US
dc.identifier.issn1432-086Xen_US
dc.identifier.issue2en_US
dc.identifier.pmid22610300en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage498en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00270-012-0419-8
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29813
dc.identifier.volume36en_US
dc.identifier.wosWOS:000316202000027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofCARDIOVASCULAR AND INTERVENTIONAL RADIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnkaferden_US
dc.subjectEmbolizationen_US
dc.subjectRenal arteryen_US
dc.subjectTranscatheteren_US
dc.titleShort-Term Effects of Ankaferd Hemostat for Renal Artery Embolization: An Experimental Studyen_US
dc.typeArticleen_US

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