Gender-Related Changes of the Epicardial Fat Thickness and Leptin in Obstructive Sleep Apnea

Basit Öğe Kaydı
dc.contributor.authorAkıllı, Hakan
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorBekçi, Taha Tahir
dc.contributor.authorErdoğan, Halil Ibrahim
dc.contributor.authorArıbaş, Alpay
dc.contributor.authorYıldırım, Oğuzhan
dc.contributor.authorTaner, Alpaslan
dc.date.accessioned2020-03-26T18:50:52Z
dc.date.available2020-03-26T18:50:52Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackgroundEpicardial fat thickness (EFT), an indicator of visceral obesity, and leptin are 2 novel markers for studying the obstructive sleep apnea (OSA) population. This study aimed to investigate the effects of gender on leptin levels and EFT, and the relation with OSA severity. MethodsA total of 149 patients with OSA (female/male 55/94 and mean age 50.89.2 years) and 50 control patients (female/male 24/26 and mean age 48.98.8 years) were included in the study. The study population was divided into 4 groups according to apnea/hypopnea index (AHI) as control (AHI <5), the mild OSA (AHI 5-14), the moderate OSA (AHI 15-29), and the severe OSA (AHI 30). EFT was obtained from parasternal long-axis and parasternal short-axis echocardiographic images. ResultsLeptin levels among females were significantly higher than among males (10.5 [7.8] vs. 5.4 [4.5] ng/mL, P=0.001, respectively). Among women, leptin levels were significantly higher in the severe OSA group compared to the control group (9.8 [9.0] vs. 15.5 [10.1] ng/mL, P=0.05, respectively). Conversely, no relation was observed between OSA severity and the leptin levels among men. EFT was not significantly different between the 2 genders (P>0.05). EFT was thicker in the severe OSA group than in the control and mild OSA groups among women, whereas EFT was not changed according to OSA severity among males (P>0.05). ConclusionLeptin and EFT may be a valuable parameter in the evaluation of OSA severity in women than in men.en_US
dc.identifier.doi10.1111/echo.12392en_US
dc.identifier.endpage419en_US
dc.identifier.issn0742-2822en_US
dc.identifier.issn1540-8175en_US
dc.identifier.issue4en_US
dc.identifier.pmid24304225en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage411en_US
dc.identifier.urihttps://dx.doi.org/10.1111/echo.12392
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30887
dc.identifier.volume31en_US
dc.identifier.wosWOS:000333757200011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectepicardial faten_US
dc.subjectgenderen_US
dc.subjectleptinen_US
dc.subjectobstructive sleep apneaen_US
dc.titleGender-Related Changes of the Epicardial Fat Thickness and Leptin in Obstructive Sleep Apneaen_US
dc.typeArticleen_US

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