Cataractous changes in rat lens following cigarette smoke exposure is prevented by parenteral deferoxamine therapy

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dc.contributor.authorAvunduk, AM
dc.contributor.authorYardimci, S
dc.contributor.authorAvunduk, MC
dc.contributor.authorKurnaz, L
dc.date.accessioned2020-03-26T16:27:03Z
dc.date.available2020-03-26T16:27:03Z
dc.date.issued1999
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: To test whether iron accumulation in the lens following cigarette smoke exposure is the principal mechanism in smoke-related cataractogenesis and to assess the possible protective effect of deferoxamine mesylate treatment against lenticular degeneration with in vivo exposure to cigarette smoke. Methods: Thirty-two male Wistar rats were randomly divided into 4 equal groups. Groups 3 and 4 rats were exposed to cigarette smoke for I hour each day for 90 consecutive days, and groups 1 and 2 rats were treated in a similar manner but exposed only to room air. In addition, deferoxamine was given subcutaneously to groups 2 and 4 rats. Both eyes of all the animals were then enucleated and 1 eye prepared for histopathological examination. The fellow eye was used to measure iron, calcium, zinc, and cop-per levels. Results: Significantly higher iron and calcium and lower zinc levels were observed in the lenses of group 3 rats compared with those in the other groups. Similar comparisons performed between groups 1 and 2, 1 and 4, and 2 and 4 did not show any significant difference. Copper concentrations did not differ between groups. Distinct histopathological changes in the anterior lens epithelium, such as hyperplasia, hypertrophy, and epithelial multilayering, and the presence of swollen epithelial cells overlying the posterior lens capsule, observed in group 3 rats, were not present in the other groups. Conclusions: Cataractogenesis following cigarette smoke exposure in rats was associated with the accumulation of iron, and concurrent deferoxamine therapy prevented such cataract formation. Clinical Relevance: Our results may apply to human cataract formation associated with cigarette smoking, so such pathogenesis may be prevented by concurrent parenteral deferoxamine treatment Clinical studies are needed, however, to determine the value of this suggestion.en_US
dc.identifier.doi10.1001/archopht.117.10.1368en_US
dc.identifier.endpage1372en_US
dc.identifier.issn0003-9950en_US
dc.identifier.issue10en_US
dc.identifier.pmid10532446en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1368en_US
dc.identifier.urihttps://dx.doi.org/10.1001/archopht.117.10.1368
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16935
dc.identifier.volume117en_US
dc.identifier.wosWOS:000083055700011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAMER MEDICAL ASSOCen_US
dc.relation.ispartofARCHIVES OF OPHTHALMOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleCataractous changes in rat lens following cigarette smoke exposure is prevented by parenteral deferoxamine therapyen_US
dc.typeArticleen_US

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