Effects of Bupivacaine and Ropivacaine on the Isolated Human Umbilical Artery

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dc.contributor.authorBarışkaner, Hülagü
dc.contributor.authorTuncer, Sema
dc.contributor.authorTaner, A.
dc.contributor.authorDoğan, N.
dc.date.accessioned2020-03-26T16:45:39Z
dc.date.available2020-03-26T16:45:39Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this in vitro study on the human umbilical artery, the effects of N(omega)-nitro-L-arginine methyl ester (L-NAME), indomethacin, prazosin, yohimbine and propranolol on the responses induced by bupivacaine and ropivacaine were investigated. Arteries isolated from umbilical cords from women who did not exhibit systemic diseases, who were not on medication and who had normal full-term deliveries, were cut into spiral strips 12 x 3 mm. Strips were mounted in organ baths at 37 degreesC continuously gassed with 5% CO2 in oxygen. The responses to the drugs were recorded isometrically on a polygraph. In the bupivacaine study, when we administered cumulative concentrations of bupivacaine (10(-9)-10(-4) M; n = 6) on basal tonus, there was no relaxation or contraction response on the tissue. Strips were precontracted with serotonin (10(-6) M 5-HT) then bupivacaine (10(-9)-10(-4) M) was directly administered cumulatively. In the ropivacaine group, when cumulative concentrations of ropivacaine (10(-9)-10(-4) M; n = 6) were administered on the tissue, preconstricted with 5-HT, ropivacaine did not alter the contraction response. Ropivacaine (10(-9)-10(-4) M) was directly administered to the bath. Though bupivacaine produced relaxation, ropivacaine produced contraction (P < 0.05). Indomethacin, prazosin, yohimbine and propranolol did not significantly alter these responses. In addition, it was demonstrated that L-NAME did not affect the relaxation responses induced by bupivacaine. Thus adrenergic receptors, nitric oxide syntenaze and prostaglandins do not appear to affect the responses induced by these two local anesthetics.en_US
dc.identifier.citationBarışkaner, H., Tuncer, S., Taner, A., Doğan, N., (2003). Effects of Bupivacaine and Ropivacaine on the Isolated Human Umbilical Artery. International Journal of Obstetric Anesthesia, (12), 261-265. Doi:10.1016/S0959-289X(03)00072-4
dc.identifier.doi10.1016/S0959-289X(03)00072-4en_US
dc.identifier.endpage265en_US
dc.identifier.issn0959-289Xen_US
dc.identifier.pmid15321454en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage261en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S0959-289X(03)00072-4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18442
dc.identifier.volume12en_US
dc.identifier.wosWOS:000186271500005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBarışkaner, Hülagü
dc.institutionauthorTuncer, Sema
dc.institutionauthorTaner, A.
dc.institutionauthorDoğan, N.
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofInternational Journal of Obstetric Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEffects of Bupivacaine and Ropivacaine on the Isolated Human Umbilical Arteryen_US
dc.typeArticleen_US

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