Effect of Acticoat (R) and Cutinova Hydro (R) on wound healing

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dc.contributor.authorArican, Mustafa
dc.contributor.authorHatipoglu, Fatih
dc.contributor.authorUyaroglu, Aysen
dc.contributor.authorOzdemir, Ozgur
dc.contributor.authorOzkan, Kadircan
dc.date.accessioned2020-03-26T18:41:35Z
dc.date.available2020-03-26T18:41:35Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, the effects of the wound-covering materials, Acticoat((R)) and Cutinova Hydro((R)), on wound healing have been studied in rabbit models with open and tissue-lost wounds with full-thickness flank excisions. Rabbits were used as subjects with three groups of four rabbits each, and trial periods of 7, 14 and 21{\uns}days. Four circular wounds, of 1.5 cm diameter were made two on the right (one of them control) and two on the left (one of them control) of the dorsal sides of the abdomen. Acticoat((R)) and Cutinova Hydro((R)) were applied on the wounds with suture for a period of 21 days and one each placed on the right and left sides as control with gauze. Biopsy specimens were taken from the animals at the end of the research period to check the length of the epithelium, epithelial thickness, size of wounds, wound granulation tissue formation and histopathological evaluation for clarity. The Acticoat((R)) group showed better healing and scar formation compared to the Cutinova Hydro((R)) group by macroscopic examination. Epithelial wound length and clarity in terms of statistical difference occurred on day 21 (P <0.05); while the length of the wound epithelium decreased patency, epithelial thickness on days similar to 7, 14 and 21, showed no statistical differences (P >0.05). As a result, the Acticoat((R)) wound dressing was determined as a more reliable for the early wound healing. This study has shown the short-term clinical benefits of hydroactive, polyurethane dressings in the management of acute wounds. However, longer periods of wound healing procedure should be planned for reliable and safe results of wound dressing. It has also been concluded that microbiological analyses should be included for more robust and reliable comparisons.en_US
dc.identifier.doi10.1111/j.1742-481X.2012.01021.xen_US
dc.identifier.endpage554en_US
dc.identifier.issn1742-4801en_US
dc.identifier.issue5en_US
dc.identifier.pmid22682153en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage549en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1742-481X.2012.01021.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29405
dc.identifier.volume10en_US
dc.identifier.wosWOS:000325090300012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofINTERNATIONAL WOUND JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectActicoat (R)en_US
dc.subjectClinical-pathological observationen_US
dc.subjectCutinova Hydro (R)en_US
dc.subjectWound healingen_US
dc.titleEffect of Acticoat (R) and Cutinova Hydro (R) on wound healingen_US
dc.typeArticleen_US

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