The Effects of Gabapentin Therapy on Pruritus, Quality of Life, Depression and Sleep Quality in Pruritic Hemodialysis Patients

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dc.contributor.authorTol, Hüseyin
dc.contributor.authorAtalay, Hüseyin
dc.contributor.authorGüney, İbrahim
dc.contributor.authorGökbel, Hakkı
dc.contributor.authorAltıntepe, Lütfullah
dc.contributor.authorBüyükbaş, Sadık
dc.contributor.authorBodur, Said
dc.date.accessioned2020-03-26T18:05:16Z
dc.date.available2020-03-26T18:05:16Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.descriptionJoint Meeting of the Slovak-Physiological-Society/Physiological-Society/Federation-of-European-Physiological-Societies -- SEP 11-14, 2007 -- Bratislava, SLOVAKIAen_US
dc.description.abstractObjectives: We aimed to determine possible changes in pruritus, quality of life, depression and sleep quality in pruritic hemodialysis (HD) patients with gabapentin therapy. Patients and Methods: Fourteen adult HD patients (7 men, 7 women; mean age 59.7 +/- 17.2 years; range 41 to 88 years) with history of pruritus of more than eight weeks were assigned to receive 8-week gabapentin (300 mg per day) therapy. The daily pruritus were recorded using visual analogue scale for each period of the study during one week preceding the trial, the active treatment phase, the placebo phase and the intervening 1-week washout period. Sleep quality was determined with a modified post-sleep inventory, quality of life with a short form of Medical Outcomes Study (SF-36), depression using the Beck Depression Inventory. Results: The mean pruritus score and total of post-sleep inventory were decreased significantly with gabapentin therapy (p=0.01 and p=0.002 respectively). Physical and mental component scales of SF-36 increased, whereas cognitive and somatic depression index decreased with gabapentin. Conclusion: We concluded that beneficial effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality are clinically important in HD patients with pruritus. Gabapentin therapy should be taken into account as an important choice of therapy in pruritic HD patients.en_US
dc.description.sponsorshipSlovak Physiol Soc, Physiol Soc, Federat European Physiol Socen_US
dc.identifier.endpage5en_US
dc.identifier.issn1301-3149en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25367
dc.identifier.volume27en_US
dc.identifier.wosWOS:000277173500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAVES YAYINCILIK, IBRAHIM KARAen_US
dc.relation.ispartofTRAKYA UNIVERSITESI TIP FAKULTESI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGabapentinen_US
dc.subjectpruritusen_US
dc.subjectquality of lifeen_US
dc.subjecthemodialysisen_US
dc.titleThe Effects of Gabapentin Therapy on Pruritus, Quality of Life, Depression and Sleep Quality in Pruritic Hemodialysis Patientsen_US
dc.typeArticleen_US

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