The protective effect of avocado soybean unsaponifilables on brain ischemia/reperfusion injury in rat prefrontal cortex

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dc.contributor.authorEser, Olcay
dc.contributor.authorSongur, Ahmet
dc.contributor.authorYaman, Mehmet
dc.contributor.authorCosar, Murat
dc.contributor.authorFidan, Huseyin
dc.contributor.authorSahin, Onder
dc.contributor.authorMollaoglu, Hakan
dc.date.accessioned2020-03-26T18:17:07Z
dc.date.available2020-03-26T18:17:07Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObject. We investigated the protective effects of avocado/soybean unsaponifiables (ASU) on the prefrontal cortex (PFC) after global brain ischemia/reperfusion (I/R) injury in rats. Methods. Rats were randomly divided into three experimental groups as follows: Group I was control rats, Group II was ischemia rats, Group III was Isch+ASU rats. Brain ischemia was produced via four-vessel occlusion model. These processes followed by reperfusion for 30 min for both II and III groups. Rats were sacrificed and their brains were removed immediately. Malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in left PFC, levels of TNF-alpha concentration were measured in the plasma. The number of apoptotic neurons was assayed in histological samples of the right PFC. Results. MDA and TNF-alpha levels as well as the number of apoptotic neurons were observed to have decreased significantly in Group III compared to Group II, while SOD activities have been found to have increased significantly in Group III in comparison to Group II, significantly. Conclusions. We think that ASU might have an antioxidant and neuroprotective effects in brain I/R injured rats.en_US
dc.description.sponsorshipKocatepe University Scientific Research CommitteeAfyon Kocatepe University [051.TIP.14]en_US
dc.description.sponsorshipThis study was supported by the Kocatepe University Scientific Research Committee (Project no. 051.TIP.14). The authors alone are responsible for the content and writing of the paper.en_US
dc.identifier.doi10.3109/02688697.2010.520767en_US
dc.identifier.endpage706en_US
dc.identifier.issn0268-8697en_US
dc.identifier.issn1360-046Xen_US
dc.identifier.issue6en_US
dc.identifier.pmid20874457en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage701en_US
dc.identifier.urihttps://dx.doi.org/10.3109/02688697.2010.520767
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26982
dc.identifier.volume25en_US
dc.identifier.wosWOS:000297337800008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofBRITISH JOURNAL OF NEUROSURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAvocado/soybean unsaponifiablesen_US
dc.subjectbrain ischemia/reperfusionen_US
dc.subjectprefrontal cortexen_US
dc.titleThe protective effect of avocado soybean unsaponifilables on brain ischemia/reperfusion injury in rat prefrontal cortexen_US
dc.typeArticleen_US

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