Magnetic nanoparticles-serum proteins bioconjugates for binding of irinotecan

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dc.contributor.authorTamyurek, Ecem
dc.contributor.authorMaltas, Esra
dc.contributor.authorBas, Salih Zeki
dc.contributor.authorOzmen, Mustafa
dc.contributor.authorYildiz, Salih
dc.date.accessioned2020-03-26T19:06:17Z
dc.date.available2020-03-26T19:06:17Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe binding of irinotecan to serum proteins (hemoglobin, globulin and human serum albumin) was studied on the surface of epoxide modified superparamagnetic iron oxide nanoparticles (GPT'S-SPIONs), which were synthesized by the coprecipitation of ferrous and ferric salts with NH4OH and then modified with [3-(2,3-epoxypropoxy)propyl] trimethoxy silane (GPTS) to obtain functional epoxide groups on the SPIONs' surface. Results were compared to find an alternative as drug carries system. Data showed that binding amount of human serum albumin (HSA), globulin (Gib) and hemoglobin (Hb) found to be as 44, 21.2 and 32.6 mu g per 20 mg of GPTS modified SPIONs, respectively. The thermal behavior of the serum protein-Ir interaction on GPTS-SPIONs was also studied by using thermo gravimetric analysis (TGA) technique and then the kinetic parameters for the thermal decomposition were determined using Horowitz-Metzger method. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipResearch Foundation of Selcuk University (Konya, Turkey)Selcuk Universityen_US
dc.description.sponsorshipWe would like to thank The Research Foundation of Selcuk University (Konya, Turkey) for financial support of this work.en_US
dc.identifier.doi10.1016/j.ijbiomac.2014.10.061en_US
dc.identifier.endpage83en_US
dc.identifier.issn0141-8130en_US
dc.identifier.issn1879-0003en_US
dc.identifier.pmid25445689en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage76en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijbiomac.2014.10.061
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32305
dc.identifier.volume73en_US
dc.identifier.wosWOS:000349194300012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIrinotecanen_US
dc.subjectMagnetic nanoparticlesen_US
dc.subjectProteinen_US
dc.subjectFluorescence spectroscopyen_US
dc.subjectHorowitz-Metzger methoden_US
dc.titleMagnetic nanoparticles-serum proteins bioconjugates for binding of irinotecanen_US
dc.typeArticleen_US

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