THE DUAL EFFECTS OF LEPTIN ON AORTIC RINGS WITH AND WITHOUT ENDOTHELIUM ISOLATED FROM STREPTOZOTOCIN-INDUCED DIABETIC RATS

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dc.contributor.authorSahin, A. S.
dc.contributor.authorBariskaner, H.
dc.contributor.authorGoekbel, H.
dc.contributor.authorOkudan, N.
dc.date.accessioned2020-03-26T17:40:30Z
dc.date.available2020-03-26T17:40:30Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to examine the effects of leptin on aortic rings with and without endothelium isolated from streptozotocin (STZ)induced diabetic and control rots, and also in the presence of on inhibitor of nitric oxide synthase (NOS). Thoracic aortic rings from 5-week STZ-induced diabetic (50 mg/kg i.p.) and age-matched control Sprague-Dawley rots were mounted in isolated tissue baths. Concentration-response curves to leptin (0.1 pM-1 nM) were constructed under basal tone and after precontraction with I PM phenylephrine in the presence or absence of N-omega-nitro-L-arginine methyl ester (L-NAME, 10 mu M). Leptin caused a concentration-dependent relaxation of precontracted endothelium-intact aortic rings from control and diabetic rots. Responses to leptin in diabetic aorta were significantly increased compared to those of controls (P < 0.05). EC50 values for leptin were similar for aortic rings from diabetic and control rots (P > 0.05). L-NAME pretreatment caused complete inhibition of the relaxant responses to leptin in the control aortic rings, while it induced a reduction in these responses in the diabetic rings (P < 0.05). Leptin-induced relaxation was eliminated when the endothelium was denuded. Leptin hod no effect on the basal tone of endothelium-intact or -denuded aortic rings from control rots. In diabetic rings, leptin elicited concentration-dependent contractions (P < 0.05). Removal of the endothelium significantly increased the contractile effect of leptin on basal tone in diabetic rings (P < 0.05). The results suggest that leptin may induce vasodilatation by endothelial mechanism(s) other than nitric oxide (NO) release from the endothelium in diabetic aortic rings. On the other hand, leptin causes contractile effects on the basal tone in aorta smooth muscle isolated from STZ-induced diabetic rots. The contractile effect of leptin on basal tone may contribute to the development of hypertension in diabetes.en_US
dc.description.sponsorshipScientific Research and Project Coordinator of Selcuk UniversitySelcuk University [RAP 06401017, RAP 07202014]en_US
dc.description.sponsorshipThis study was completed with support from two funds of from the Scientific Research and Project Coordinator of Selcuk University (Fund numbers: RAP 06401017 and RAP 07202014).en_US
dc.identifier.doi10.1358/mf.2009.31.5.1386593en_US
dc.identifier.endpage329en_US
dc.identifier.issn0379-0355en_US
dc.identifier.issn2013-0155en_US
dc.identifier.issue5en_US
dc.identifier.pmid19649339en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage325en_US
dc.identifier.urihttps://dx.doi.org/10.1358/mf.2009.31.5.1386593
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23915
dc.identifier.volume31en_US
dc.identifier.wosWOS:000270181400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPROUS SCIENCE, SAU-THOMSON REUTERSen_US
dc.relation.ispartofMETHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectLeptinen_US
dc.subjectAortaen_US
dc.subjectDiabetesen_US
dc.subjectRaten_US
dc.titleTHE DUAL EFFECTS OF LEPTIN ON AORTIC RINGS WITH AND WITHOUT ENDOTHELIUM ISOLATED FROM STREPTOZOTOCIN-INDUCED DIABETIC RATSen_US
dc.typeArticleen_US

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