Amelioration of radiation-induced acute inflammation and mucosal atrophy by beta-hydroxy-beta-methylbutyrate, L-glutamine, and L-arginine: results of an experimental study

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dc.contributor.authorYavas, Cagdas
dc.contributor.authorYavas, Guler
dc.contributor.authorAcar, Hilal
dc.contributor.authorToy, Hatice
dc.contributor.authorYuce, Deniz
dc.contributor.authorAkyurek, Serap
dc.contributor.authorAta, Ozlem
dc.date.accessioned2020-03-26T18:41:05Z
dc.date.available2020-03-26T18:41:05Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe aimed to evaluate the effects of beta-hydroxy-beta-methylbutyrate, l-glutamine, and l-arginine (HMB/Glu/Arg) on radiation-induced acute inflammation and mucosal atrophy in the oral mucosa. Twenty-eight rats were divided into four groups. group (G) 1 was defined as control group, and G2 was the radiation therapy (RT) group. G3 and G4 were HMB/Glu/Arg control and 17 Gy RT plus HMB/Glu/Arg groups, respectively. A single dose of 17 Gy RT was given to the head and neck area, and the active supplement consisting of 5.2 g of HMB, 29.6 g arginine, and 29.6 g of glutamine which was equivalent to 60 kg adult dose was calculated for each rat and administrated orally. HMB/Glu/Arg started from the day of RT and continued until the animals were sacrificed 7 days after the RT. The extent of acute inflammation and mucosal atrophy for each rat was quantified with image analysis of histological sections of the oral mucosa. There were significant differences in terms of epithelial thickness, subepithelial edema, inflammation, and congestion between all groups (p values were < 0.001, 0.003, < 0.001, and 0.001 for each parameter, respectively). Using HMB/Glu/Arg alone led to hypertrophic changes in the epithelial layer. Moreover, when used with RT, HMB/Glu/Arg reversed radiation-induced epithelial atrophy (p, 0.006) and decreased radiation-induced inflammation at a significant level (p, 0.007). Concomitant use of HMB/Glu/Arg appears to ameliorate the radiation-induced acute inflammation and mucosal atrophy which represent the early phase of acute oral mucositis; however, this finding should be clarified with further clinical studies.en_US
dc.identifier.doi10.1007/s00520-012-1601-xen_US
dc.identifier.endpage888en_US
dc.identifier.issn0941-4355en_US
dc.identifier.issn1433-7339en_US
dc.identifier.issue3en_US
dc.identifier.pmid22993027en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage883en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00520-012-1601-x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29205
dc.identifier.volume21en_US
dc.identifier.wosWOS:000314301900026en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofSUPPORTIVE CARE IN CANCERen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBeta-hydroxy-beta-methylbutyrateen_US
dc.subjectEssential amino acidsen_US
dc.subjectOral mucositisen_US
dc.subjectRadiotherapyen_US
dc.titleAmelioration of radiation-induced acute inflammation and mucosal atrophy by beta-hydroxy-beta-methylbutyrate, L-glutamine, and L-arginine: results of an experimental studyen_US
dc.typeArticleen_US

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