The Effects of Florfenicol on the Values of Serum Tumor Necrosis Factor-alpha and Other Biochemical Markers in Lipopolysaccharide-Induced Endotoxemia in Brown Trout

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dc.contributor.authorEr, Ayse
dc.contributor.authorDik, Burak
dc.date.accessioned2020-03-26T18:58:36Z
dc.date.available2020-03-26T18:58:36Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of the present study was to determine the effects of florfenicol on the expected changes in sTNF-alpha.,damagemarkers of the liver and kidney, and the lipid metabolism parameters in endotoxemic brown trout. Ninety-six brown trout were included in this study. After six of the fish were reserved as the control group, the remaining 90 fish were divided equally into 3 groups as follows: LPS ( 2mg/kg, IP), LPS (2mg/kg, IP) + florfenicol (40mg/kg, IM), and florfenicol (40mg/kg, IM). Blood samples were obtained from the tail of the fish at 1.5, 3, 6, 10, and 24 hours. The levels of sTNF-alpha were determined by ELISA and biochemical markers were evaluated with an autoanalyzer. A significant increase was observed in the values of sTNF-alpha in the LPS and LPS + florfenicol groups (P < 0.05). Significant increases were found in the kidney and liver damage determinants in the LPS and LPS + florfenicol groups (P < 0.05). Irregular changes in the lipid metabolism parameters were observed in all the subgroups. In conclusion, florfenicol does not affect the increases of sTNF-alpha caused by LPS and does not prevent liver or kidney damage; at least, it can be said that florfenicol does not have any evident positive effects on the acute endotoxemia of fish.en_US
dc.identifier.doi10.1155/2014/464373en_US
dc.identifier.issn0962-9351en_US
dc.identifier.issn1466-1861en_US
dc.identifier.pmid24876673en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1155/2014/464373
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31199
dc.identifier.wosWOS:000335741400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHINDAWI LTDen_US
dc.relation.ispartofMEDIATORS OF INFLAMMATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe Effects of Florfenicol on the Values of Serum Tumor Necrosis Factor-alpha and Other Biochemical Markers in Lipopolysaccharide-Induced Endotoxemia in Brown Trouten_US
dc.typeArticleen_US

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