The clinical value and histopathological correlation of lacrimal scintigraphy in patients with primary Sjogren's syndrome

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dc.contributor.authorErhamamcı, Seval
dc.contributor.authorKaralezli, Aylin
dc.contributor.authorYılmaz, Sema
dc.contributor.authorAktaş, Ayşe
dc.date.accessioned2020-03-26T18:31:33Z
dc.date.available2020-03-26T18:31:33Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose To evaluate the lacrimal gland function in patients with primary Sjogren's syndrome (SS) using lacrimal scintigraphy (LS) and to determine the relationship between clinicopathological stage of primary SS and LS findings. Methods Seventy eyes from 35 patients with primary SS and 20 eyes from 10 healthy age-matched and sex-matched individuals who served as the control group were included in this study. The patients with primary SS were divided into two groups - early stage and advanced stage - according to the labial biopsy scores (23 patients in early stage and 12 in advanced stage). LS, the Schirmer-1 test, determination of break-up time (BUT), Rose bengal ocular surface vital staining and assessment of functional parameters including ocular surface disease index (OSDI) scores were performed for all cases. LS was used to evaluate tear clearance. Lacrimal scintigrams were evaluated for the presence and severity of delayed tear clearance. Delay in clearance was also subclassified according to the severity of delay (mild, moderate, severe and very severe). LS findings and ophthalmological test results of patients in early stage of disease were compared with the results of those in advanced stage and with those of normal individuals. Result The Schirmer-1 test and BUT values of patients in advanced stage of primary SS decreased significantly, whereas the Rose bengal and OSDI values increased significantly when compared with the values of patients in early stage of primary SS and with those of normal individuals (P<0.05 and P<0.001, respectively). Tear clearance of patients in advanced-stage disease was delayed significantly, compared with the tear delay in patients in early stage of disease and that of normal individuals (P<0.001). An inverse correlation existed between tear clearance and both the Schirmer-1 test and BUT value in all patients (P<0.001). However, there was a positive correlation between both the Rose bengal ocular surface staining values and OSDI scores and tear clearance in all cases (P<0.001). LS findings and ophthalmologic test results were significantly different between early-stage and advanced-stage primary SS. Conclusion The results indicate that LS, which is correlated closely with ophthalmological test results, may be a useful method for the assessment of the lacrimal gland function in patients with primary SS. LS findings and ophthalmological tests may be used for determining disease severity in primary SS. Nucl Med Commun 33:689-694 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.en_US
dc.identifier.doi10.1097/MNM.0b013e328353bbf2en_US
dc.identifier.endpage694en_US
dc.identifier.issn0143-3636en_US
dc.identifier.issn1473-5628en_US
dc.identifier.issue7en_US
dc.identifier.pmid22513885en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage689en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MNM.0b013e328353bbf2
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28476
dc.identifier.volume33en_US
dc.identifier.wosWOS:000305500600002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofNUCLEAR MEDICINE COMMUNICATIONSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthistopathological stageen_US
dc.subjectlacrimal scintigraphyen_US
dc.subjectophthalmic findingsen_US
dc.subjectprimary Sjogren's syndromeen_US
dc.subjectTc-99m pertechnetateen_US
dc.titleThe clinical value and histopathological correlation of lacrimal scintigraphy in patients with primary Sjogren's syndromeen_US
dc.typeArticleen_US

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