The effect of pinealectomy on plasma vasopressin response to isotonic, hypertonic and hypovolemic treatments in rats supplemented with L-thyroxine

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dc.contributor.authorMogulkoc, R.
dc.contributor.authorBaltaci, A. K.
dc.date.accessioned2020-03-26T17:28:04Z
dc.date.available2020-03-26T17:28:04Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe present study was conducted to determine the effects of basal, isotonic as well as hypertonic and hypovolemic treatments on fluid-electrolyte balance and plasma AVP levels in rats supplemented with L-thyroxine and pinealectomized L-thyroxine. The animals were initially separated into 4 groups: control (n = 24), L-thyroxine treated (n = 24); L-thyroxine + sham-pinealectomy (n = 24) treated and 4-L-thyroxine + pinealectomy (n = 24) treated. L-thyroxine was given for 4 weeks. At the end of the 4-week experimental period, the sub-groups were formed before decapitation, which were classified as unstimulated (n = 6), isotonic (n = 6), hypertonic (n = 6) and hypovolemic (n = 6) stimulation. Plasma AVP, total triiodothyronine (TT3) and total thyroxine (TT4) levels were examined in plasma by RIA. Hematocrit and osmolality levels were also determined. It was found that the TT3 and TT4 levels showed significant increases in L-thyroxine treated groups (P < 0.001). Also, plasma AVP levels increased in the group subjected to L-thyroxine treatment. However, this increase was depicted to be significantly more prominent in L-thyroxine + pinealectomy treated group (P < 0.001). The results of the present study indicate that L-thyroxine treatment increases the basal and stimulated AVP release, which became more significant in the pinealectorny plus L-thyroxine treatment group. Moreover, the results indicate that AVP response to hypertonic and hypovolemic stimulations does not undergo any change due to supplementation by L-thyroxine treatment and/or pinealectomy plus L-thyroxine.en_US
dc.identifier.doi10.1556/ABiol.59.2008.2.3en_US
dc.identifier.endpage172en_US
dc.identifier.issn0236-5383en_US
dc.identifier.issue2en_US
dc.identifier.pmid18637556en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage163en_US
dc.identifier.urihttps://dx.doi.org/10.1556/ABiol.59.2008.2.3
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22708
dc.identifier.volume59en_US
dc.identifier.wosWOS:000256626000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAKADEMIAI KIADOen_US
dc.relation.ispartofACTA BIOLOGICA HUNGARICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAVPen_US
dc.subjectL-thyroxine treatmenten_US
dc.subjectpinealectomyen_US
dc.subjecthypertonic and hypovolemic stimulationen_US
dc.subjectosmolalityen_US
dc.subjectraten_US
dc.titleThe effect of pinealectomy on plasma vasopressin response to isotonic, hypertonic and hypovolemic treatments in rats supplemented with L-thyroxineen_US
dc.typeArticleen_US

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