The effect of leptin on penicillin-induced epileptiform activity in rats

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dc.contributor.authorAyyildiz, M
dc.contributor.authorYildirim, M
dc.contributor.authorAgar, E
dc.contributor.authorBaltaci, AK
dc.date.accessioned2020-03-26T17:04:32Z
dc.date.available2020-03-26T17:04:32Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractLeptin is an adipose tissue-derived peptide hormone, which acts as a satiety factor to reduce appetite by interactions with hypothalamic neurons. The other possible physiological functions of leptin are still unclear. In this study, we have evaluated dose-dependent effect of leptin on penicillin-induced epileptiform activity, analyzed by electrocorticogram (ECoG). The epileptiform activity was induced by microinjection of penicillin into the left sensorymotor cortex. Thirty minutes after penicillin injection, 1, 2 or 10 mu g of leptin was administrated intracerebroventricularly (i.c.v.). Leptin (1, 2 or 10 mu g) alone did not significantly change the spike amplitudes in non-penicillin pretreated control animals. One or two micrograms of leptin significantly increased the frequency of epileptiform activity in the penicillin-pretreated animals. The high dose of leptin (10 mu g) did not significantly change either amplitude or frequency of epileptiform activity. One microgram i.c.v. leptin was the most effective dose in changing of frequency on penicillin-induced epileptiform activity. The proconvulsant effects of leptin appeared 90 min after leptin (I and 2 jig) injection. These data indicate that leptin increases the frequency of penicillin-induced epileptic activity. We speculate that this action of leptin might suggest that leptin may be a proconvulsant substance. 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.brainresbull.2005.09.012en_US
dc.identifier.endpage378en_US
dc.identifier.issn0361-9230en_US
dc.identifier.issn1873-2747en_US
dc.identifier.issue5en_US
dc.identifier.pmid16377445en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage374en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.brainresbull.2005.09.012
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20723
dc.identifier.volume68en_US
dc.identifier.wosWOS:000234656400011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofBRAIN RESEARCH BULLETINen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectleptinen_US
dc.subjectpenicillinen_US
dc.subjectepileptiform activityen_US
dc.subjectECoGen_US
dc.titleThe effect of leptin on penicillin-induced epileptiform activity in ratsen_US
dc.typeArticleen_US

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