The effect of platelet-rich plasma on osteochondral defects treated with mosaicplasty

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dc.contributor.authorAltan, Egemen
dc.contributor.authorAydin, Kerem
dc.contributor.authorErkocak, Omer
dc.contributor.authorSenaran, Hakan
dc.contributor.authorUgras, Serdar
dc.date.accessioned2020-03-26T18:58:35Z
dc.date.available2020-03-26T18:58:35Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose This study investigated the efficacy of platelet-rich plasma (PRP) on articular surfaces on which the mosaicplasty technique was performed. Our hypothesis was that PRP can accelerate the osseointegration process and enhance the quality of articular integrity after the mosaicplasty procedure. Methods Standard defects were created in the femoral groove of both patellofemoral joints of 12 New Zealand rabbits. PRP solution was placed inside the defect before fixation of the osteochondral autografts and injected inside the involved joint after capsular closure of the tested knees. The contralateral knees served as the control sides. The animals were euthanized three or six weeks after mosaicplasty, and both limbs were assessed according to Pineda's histological grading scale. Significance level was set at p <= 0.05 a priori, and the Mann-Whitney U test was used for statistical analysis. Results Histologic findings at the interface between the transferred autograft and the original cartilage revealed better integration of the adjacent surfaces in the mosaicplasty with PRP group three weeks after the procedure; the difference was significant (p < 0.05). However, no significant difference in the transition zone was observed between the groups six weeks after the experiment (p = 0.59). Conclusions Our animal model showed that adjunctive use of PRP produced a better healing response and resulted in superior histological scores after three weeks compared with the mosaicplasty-only procedure. Interpretation of our results is important in terms of rapid return to previous activity levels. Thus, application of PRP can represent a valid therapeutic option for improving the efficacy of mosaicplasty by stimulating the local healing response.en_US
dc.identifier.doi10.1007/s00264-013-2275-9en_US
dc.identifier.endpage1328en_US
dc.identifier.issn0341-2695en_US
dc.identifier.issn1432-5195en_US
dc.identifier.issue6en_US
dc.identifier.pmid24430431en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1321en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00264-013-2275-9
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31190
dc.identifier.volume38en_US
dc.identifier.wosWOS:000336601000028en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofINTERNATIONAL ORTHOPAEDICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPlatelet-rich plasmaen_US
dc.subjectOsteochondral defecten_US
dc.subjectMosaicplastyen_US
dc.subjectCartilageen_US
dc.titleThe effect of platelet-rich plasma on osteochondral defects treated with mosaicplastyen_US
dc.typeArticleen_US

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