Reactive oxygen radical levels in caustic esophageal burns

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dc.contributor.authorGünel, Engin
dc.contributor.authorÇağlayan, Fatma
dc.contributor.authorÇağlayan, Osman
dc.contributor.authorAkıllıoğlu, İshak
dc.date.accessioned2020-03-26T16:27:17Z
dc.date.available2020-03-26T16:27:17Z
dc.date.issued1999
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: This study was designed to determine the tissue levels of reactive oxygen radicals in caustic esophageal burns in a rat model. Methods: Forty rats were divided into four groups of 10 animals each,The control rats were uninjured in group A, and the others were injured rats in groups B, C, and D. Through a median laparatomy incision, a 1.5-cm abdominal esophageal segment was isolated and tied with 2-0 chromic sutures in all groups as described by Gehanno. One milliliter of 10% sodium hydroxide solution in groups B, C, and D and 0.9% saline solution in group A were instilled through the isolated segment via a no. 24 cannula for 3 minutes, then the esophagus was rinsed for 1 minute with distilled water. The studied 1.5 cm of the abdominal esophagus was removed from each animal 24 hours after caustic injury in group B, 48 hours after in group C, and 72 hours after in group D. In group A, studied uninjured segments were removed for biochemical investigation. Tissue malondialdehyde (MDA) and glutathione (GSH) levels were determined for each group. Results: The mean MDA levels in esophageal tissue were significantly higher in groups B, C, and D than in group A (P < .05). Moreover, the mean GSH levels in the same esophageal tissues were significantly lower in groups C and D than in groups A and B (P < .05). Conclusion: The reactive oxygen radicals may be play an important role in early phase of caustic esophageal burns by increasing the tissue damage. Copyright (C) 1999 by W.B. Saunders Company.en_US
dc.identifier.doi10.1016/S0022-3468(99)90486-4en_US
dc.identifier.endpage407en_US
dc.identifier.issn0022-3468en_US
dc.identifier.issue3en_US
dc.identifier.pmid10211641en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage405en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S0022-3468(99)90486-4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16973
dc.identifier.volume34en_US
dc.identifier.wosWOS:000079227500007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO-ELSEVIER INCen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectesophageal burnen_US
dc.subjectcorrosiveen_US
dc.subjectreactive oxygen radicalsen_US
dc.subjectmalondialdehydeen_US
dc.subjectglutathioneen_US
dc.titleReactive oxygen radical levels in caustic esophageal burnsen_US
dc.typeArticleen_US

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