Malondialdehyde levels in adult attention-deficit hyperactivity disorder

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dc.contributor.authorBulut, Mahmut
dc.contributor.authorSelek, Salih
dc.contributor.authorGergerlioglu, H. Serdar
dc.contributor.authorSavas, Haluk A.
dc.contributor.authorYilmaz, H. Ramazan
dc.contributor.authorYuce, Murat
dc.contributor.authorEkici, Giyasettin
dc.date.accessioned2020-03-26T17:17:40Z
dc.date.available2020-03-26T17:17:40Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To evaluate the biochemical basis of adult attention-deficit hyperactivity disorder (A-ADHD), we compared lipid peroxidation status in the plasma of A-ADHD patients, and that of control subjects without A-ADHD by quantifying the levels of malondialdehyde (MDA), an end product of fatty acid oxidation. We aimed to examine the association between MDA and A-ADHD. Method: The study comprised 20 A-ADHD patients from Gaziantep University Sahinbey Research Hospital Psychiatry Clinic, diagnosed by 2 psychiatrists (H.A.S. and S.S.) according to the Turkish version of the adult ADD/ADHD DSM-IV-Based Diagnostic Screening and Rating Scale, and 21 healthy volunteers. Malondialdehyde levels were measured in plasma samples of both study groups, Results: The mean (standard deviation [SD]) MDA levels in patients (2.44 [0.84] nmol/mL) were significantly higher than those of control subjects (0.36 [0.20] nmol/mL) (t = 11.013, of = 39, p < 0.01). MDA levels were correlated with overall number of criteria met (n = 20, p = 0.01, Ro = 0.56) and total hyperactivity/impulsivity score(n = 20, p = 0.02, Ro = 0.51). Conclusion: The fact that MDA levels were increased in A-ADHD could be an indication of increased oxidative stress in this disease. We suggest that such changes may have a pathological role in A-ADHD. This is the first study evaluating the MDA levels in A-ADHD, and our findings may provide a scientific guide for the further clinical enzymologic and biochemical studies on this disorder.en_US
dc.identifier.endpage438en_US
dc.identifier.issn1180-4882en_US
dc.identifier.issn1488-2434en_US
dc.identifier.issue6en_US
dc.identifier.pmid18043768en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage435en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21466
dc.identifier.volume32en_US
dc.identifier.wosWOS:000251278100007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCMA-CANADIAN MEDICAL ASSOCen_US
dc.relation.ispartofJOURNAL OF PSYCHIATRY & NEUROSCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectadulten_US
dc.subjectattention-deficit disorder with hyperactivityen_US
dc.subjectmalondialdehydeen_US
dc.subjectoxidative stressen_US
dc.titleMalondialdehyde levels in adult attention-deficit hyperactivity disorderen_US
dc.typeArticleen_US

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