Pharmacokinetic/pharmacodynamic integration of marbofloxacin after oral and intravenous administration in rainbow trout (Oncorhynchus mykiss)

Basit Öğe Kaydı
dc.contributor.authorCorum, Orhan.
dc.contributor.authorTerzi, Ertugrul.
dc.contributor.authorCorum, Duygu Durna.
dc.contributor.authorKenanoglu, Osman Nezih.
dc.contributor.authorBilen, Soner.
dc.contributor.authorUney, Kamil.
dc.date.accessioned2020-03-26T20:20:24Z
dc.date.available2020-03-26T20:20:24Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractThe pharmaco-kinetic/dynamic of marbofloxacin was investigated after single intravenous (IV) and oral administration of 10 mg/kg in 192 healthy rainbow trout at 13 +/- 1.2 degrees C. The plasma concentrations of marbofloxacin were determined by high-performance liquid chromatography-ultraviolet detection. After IV and oral administration, the plasma concentration-time data were described by a noncompartmental analysis. The minimal inhibitory concentration (MIC) of marbofloxacin against Yersinia ruckeri, Aeromonas hydrophila, Pseudomonas fluorescens and P. putida were determined by broth dilution method at 13 degrees C. After IV administration, the elimination half-life (t(1/2)(lambda z)), area under the concentration-versus time curve (AUC(0-infinity)), apparent volume of distribution at steady-state and total body clearance of marbofloxacin were 18.05 h, 354.63 h * mu g/mL, 0.65 L/kg and 0.03 L/h/kg, respectively. After oral administration, t(1/2 lambda z), AUC(0)(-infinity) the peak plasma concentration, time of maximum concentration and bioavailability were 27.51 h, 135.29 h * mu g/mL, 3.74 mu g/mL, 4 h and 38.15%, respectively. The respective MICs of marbofloxacin against Y. ruckeri, A. hydrophila, P. fluorescens and P. putida were determined as 0.02 mu g/mL, 2.5 mu g/mL, 2.5 mu g/mL and 5 mu g/mL, respectively. Following IV and oral administration of 10 mg/kg marbofloxacin, AUC/MIC and C-max/MIC values were above the target levels for Y. ruckeri, while this dose was not sufficient for A. hydrophila and Pseudomonas spp. Because the pharmacokinetics and pharmacodynamics of a drug in fish are significantly affected by temperature, the dosage regimen of marbofloxacin should be modified according to temperature.en_US
dc.identifier.citationCorum, O., Terzi, E., Corum, D. D., Kenanoglu, O. N., Bilen, S., Uney, K. (2020). Pharmacokinetic/Pharmacodynamic Integration of Marbofloxacin After Oral and Intravenous Administration in Rainbow Trout (Oncorhynchus mykiss). Aquaculture, 514, 1-5.
dc.identifier.doi10.1016/j.aquaculture.2019.734510en_US
dc.identifier.issn0044-8486en_US
dc.identifier.issn1873-5622en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.aquaculture.2019.734510
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38579
dc.identifier.volume514en_US
dc.identifier.wosWOS:000495358600031en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorUney, Kamil.
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofAQUACULTUREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPharmacokineticsen_US
dc.subjectPharmacodynamicsen_US
dc.subjectMarbofloxacinen_US
dc.subjectRainbow trouten_US
dc.titlePharmacokinetic/pharmacodynamic integration of marbofloxacin after oral and intravenous administration in rainbow trout (Oncorhynchus mykiss)en_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Orhan CORUM.pdf
Boyut:
303.16 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Full Text Access
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Klinik Öncesi Bilimler/Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu