Increased expression of epidermal growth factor receptors in the tracheal epithelia after topical mitomycin-C in rabbits

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dc.contributor.authorArbag, H
dc.contributor.authorAvunduk, MC
dc.contributor.authorOzer, B
dc.contributor.authorOzturk, K
dc.contributor.authorUlku, CH
dc.date.accessioned2020-03-26T16:57:21Z
dc.date.available2020-03-26T16:57:21Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim is to examine histopathological changes and expression of epidermal growth factor receptor (EGFR) in tracheal epithelia caused by application of topical mitomycin-C (MMC) in rabbit model after the tracheotomy procedure. The conventional tracheotomy was performed in 16 rabbits. They were randomly divided into two equal groups. The first group was applied MMC at a concentration of 0.4 mg/ml around tracheotomy for 5 min, and the other group was not taken a treatment as a control. The animals were sacrificed at the end of 4 weeks. Their tracheas were evaluated with H&E and Masson's trichrome histochemically, and with antiepidermal growth factor receptor immunohistochemically. Results showed that there was no significant difference between MMC and control group for inflammatory cells (P = 0.09). The numbers of fibroblasts and subepithelial tissue thickness in the group exposed to MMC were significantly lower than the control group (P < 0.05). In contrast, the percentage of EGFR in the application of MMC group was significantly higher than the control croup (P < 0.05). The application of topical MMC on airway epithelia after tracheotomy showed significant elevation in the levels of epithelial EGFR expression compared to controls in a rabbit model. The activation of epithelial EGFR may facilitate epithelial healing, but further studies are needed to assess the effect of topical MMC on respiratory epithelia. (c) 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.anl.2004.11.011en_US
dc.identifier.endpage70en_US
dc.identifier.issn0385-8146en_US
dc.identifier.issn1879-1476en_US
dc.identifier.issue1en_US
dc.identifier.pmid15882829en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage65en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.anl.2004.11.011
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19769
dc.identifier.volume32en_US
dc.identifier.wosWOS:000229448000012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofAURIS NASUS LARYNXen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectepithelial regenerationen_US
dc.subjectwound healingen_US
dc.subjectEGFRen_US
dc.subjectmitomycin-Cen_US
dc.titleIncreased expression of epidermal growth factor receptors in the tracheal epithelia after topical mitomycin-C in rabbitsen_US
dc.typeArticleen_US

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