Comparison of semen profile and frequency of chromosome aneuploidies in sperm nuclei of patients with varicocele before and after varicocelectomy

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dc.contributor.authorAcar, H.
dc.contributor.authorKilinc, M.
dc.contributor.authorGuven, S.
dc.contributor.authorYurdakul, T.
dc.contributor.authorCelik, R.
dc.date.accessioned2020-03-26T17:38:06Z
dc.date.available2020-03-26T17:38:06Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractSemen profile and meiotic segregation products are important for assessing aneuploidy risk and risk of resulting infertility. To determine the effect of varicocelectomy on semen profile and aneuploidy frequency, we investigated semen profile and aneuploidy frequency of selected chromosomes in patients with varicocele before and after varicocelectomy. Chromosomal aneuploidy for selected chromosomes was evaluated using chromosome-specific DNA fluorescence in situ hybridisation (FISH) probes. There was a significant difference in the level of normal sperm morphology before and after varicocelectomy (P > 0.007). There were no significant differences in aneuploidy frequency of chromosomes 1, 16, 17 and 18 in sperm nuclei obtained from patients before varicocelectomy compared with 6-7 months after varicocelectomy (P > 0.05), although FISH analysis with chromosomes 17 and 18 combination showed a higher aneuploidy frequency before varicocelectomy than after varicocelectomy (7.81 +/- 9.67 versus 4.03 +/- 1.46 respectively). In conclusion, varicocele seems to affect the semen profile but minimally affects aneuploidy frequency. Varicocelectomy demonstrates a repairing effect on the semen profile and contributes to a slight decrease in aneuploidy frequency in some but not all chromosomes.en_US
dc.identifier.doi10.1111/j.1439-0272.2008.00907.xen_US
dc.identifier.endpage162en_US
dc.identifier.issn0303-4569en_US
dc.identifier.issn1439-0272en_US
dc.identifier.issue3en_US
dc.identifier.pmid19400849en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1439-0272.2008.00907.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23374
dc.identifier.volume41en_US
dc.identifier.wosWOS:000265480700004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofANDROLOGIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAneuploidyen_US
dc.subjectchromosomes 1en_US
dc.subject16en_US
dc.subject17en_US
dc.subject18en_US
dc.subjectFISHen_US
dc.subjectsemenen_US
dc.subjectvaricocceleen_US
dc.titleComparison of semen profile and frequency of chromosome aneuploidies in sperm nuclei of patients with varicocele before and after varicocelectomyen_US
dc.typeArticleen_US

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