Baseline characteristics of the 4011 patients recruited into the 'Efficacy of Nitric Oxide in Stroke' (ENOS) trial

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dc.contributor.authorBath, Philip M. W.
dc.contributor.authorAdami, Alessandro
dc.contributor.authorBereczki, Daniel
dc.contributor.authorBerge, Eivind
dc.contributor.authorBeridze, Maia
dc.contributor.authorCala, Lesley
dc.contributor.authorCasado, Ana
dc.date.accessioned2020-03-26T18:49:34Z
dc.date.available2020-03-26T18:49:34Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground High blood pressure is common in acute stroke and associated with a worse functional outcome. Many patients who present with acute stroke are taking prescribed antihypertensive therapy before their stroke. Aims ENOS tested whether lowering blood pressure and continuing pre-stroke antihypertensive therapy are each safe and effective. Methods This study is an international multi-centre prospective randomized single-blind blinded-endpoint parallel-group partial-factorial controlled trial of transdermal glyceryl trinitrate (a nitric oxide donor, given for seven-days) vs. no glyceryl trinitrate, and of continuing vs. stopping (temporarily for seven-days) pre-stroke antihypertensive drugs if relevant, in patients with acute ischaemic stroke or intracerebral haemorrhage and high systolic blood pressure (140-220 mmHg). Results Recruitment ran from July 2001 to October 2013. Four thousand eleven patients [2097 (52.3%) in the continue/stop arm] were recruited from 173 sites across 23 countries in 5 continents (Asia 14%, Continental Europe 16%, UK 64%). Baseline characteristics include: mean age 70 (standard deviation 12) years; male 57%; mean time from stroke to recruitment 26 (13) h; mean severity (Scandinavian Stroke Scale) 34 (13) of 58; mean blood pressure 167 (19)/90 (13) mmHg; ischaemic stroke 83%; and intracerebral haemorrhage 16%. The main trial results will be presented in May 2014. The results will also be presented in updated Cochrane systematic reviews and included in individual patient data meta-analyses of all relevant randomized controlled trials. Conclusion ENOS is a large completed international trial of blood pressure management in acute stroke and includes patients representative of many stroke services worldwide.en_US
dc.description.sponsorshipUK Medical Research CouncilMedical Research Council UK (MRC); Bupa Foundation; Hypertension Trust; Queen Elizabeth II Health Sciences Centre Research Fund; Reichstadt family; Stroke Association; UK NIHR, through the Stroke Research Networken_US
dc.description.sponsorshipWe thank all the patients, and their carers, for participating in the trial. The UK Medical Research Council was the primary funder; we thank them and other funders who supported the trial: A Star, Bupa Foundation, Hypertension Trust, Queen Elizabeth II Health Sciences Centre Research Fund, Reichstadt family, and The Stroke Association (through its funding of the Division of Stroke, University of Nottingham). ENOS acknowledges the support of the UK NIHR, through the Stroke Research Network. Finally, we thank the members of the independent data monitoring committee who supervised safety from the beginning to the end of the trial.en_US
dc.identifier.doi10.1111/ijs.12308en_US
dc.identifier.endpage720en_US
dc.identifier.issn1747-4930en_US
dc.identifier.issn1747-4949en_US
dc.identifier.issue6en_US
dc.identifier.pmid25043647en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage711en_US
dc.identifier.urihttps://dx.doi.org/10.1111/ijs.12308
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30637
dc.identifier.volume9en_US
dc.identifier.wosWOS:000339477400012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF STROKEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectacute strokeen_US
dc.subjectantihypertensive drugsen_US
dc.subjectblood pressureen_US
dc.subjectglyceryl trinitrateen_US
dc.subjectnitric oxideen_US
dc.subjectrandomized controlled trialen_US
dc.titleBaseline characteristics of the 4011 patients recruited into the 'Efficacy of Nitric Oxide in Stroke' (ENOS) trialen_US
dc.typeArticleen_US

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