In vitro evaluation of enrofloxacin-loaded MLV Liposomes

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dc.contributor.authorSezer, Ali Demir
dc.contributor.authorAkbuğa, Julide
dc.contributor.authorBaş, Ahmet Levent
dc.date.accessioned2020-03-26T17:17:32Z
dc.date.available2020-03-26T17:17:32Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractFluoroquinolones are broad-spectrum antimicrobial agents that seem to reach their intracellular target site ( DNA gyrase) in Escherichia coli by means of an uptake process through the outer and inner membranes. Delivery of quinolones with liposomes has many advantages than the free form of the drug. Liposomes may represent an excellent device for improving the selective transport of antibiotics in these respects. In this study, enrofloxacin-loaded multilamellar vesicles (MLVs) were prepared and the effects of formulation variables on the liposome characteristics were investigated. Liposomes were prepared by using the dry lipid film method. A number of variables, such as phospholipid (DL-alpha-phosphatidylcholine dipalmitoyl), cholesterol, enrofloxacin (ENF), stearylamine, and dicetyl phosphate molar ratios and alpha-tocopherol amounts, were studied. The liposome size, encapsulation capacity, drug release, stability, and electrophoretic mobility of ENF-loaded liposomes were determined. Using this method, spherical MLVs with high drug content could be produced. Particle size of liposomes changed between 1.63 and 3.31 mu m and liposome size was affected by all formulation variables ( p < 0.05) except molar ratio of ENF. MLVs can be used as a carrier system for the controlled release of ENF. The highest encapsulation of ENF amount can be obtained using positively charged SA in the formulation and changing the formulation parameters can vary drug release patterns.en_US
dc.identifier.doi10.1080/10717540600640146en_US
dc.identifier.endpage53en_US
dc.identifier.issn1071-7544en_US
dc.identifier.issue1en_US
dc.identifier.pmid17107930en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://dx.doi.org/10.1080/10717540600640146
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21427
dc.identifier.volume14en_US
dc.identifier.wosWOS:000242046200006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINFORMA HEALTHCAREen_US
dc.relation.ispartofDRUG DELIVERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcontrolled releaseen_US
dc.subjectdrug encapsulationen_US
dc.subjectenrofloxacinen_US
dc.subjectformulationen_US
dc.subjectliposomeen_US
dc.subjectMLVen_US
dc.subjectstabilityen_US
dc.subjectzeta potentialen_US
dc.titleIn vitro evaluation of enrofloxacin-loaded MLV Liposomesen_US
dc.typeArticleen_US

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