Clinicopathologic Features and Molecular Subtypes of Breast Cancer in Young Women (Age <= 35)

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dc.contributor.authorGoksu, Sema Sezgin
dc.contributor.authorTastekin, Didem
dc.contributor.authorArslan, Deniz
dc.contributor.authorGunduz, Seyda
dc.contributor.authorTatli, Ali Murat
dc.contributor.authorUnal, Dilek
dc.contributor.authorSalim, Derya
dc.date.accessioned2020-03-26T18:49:44Z
dc.date.available2020-03-26T18:49:44Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction: Breast cancer in young women is a relatively rare disease; however it tends to be more aggressive and is the leading cause of cancer death in this population. The aim of this study is to investigate the clinical and biological features of breast cancer arising in young Turkish breast cancer patients. Materials and Methods: Patients with breast cancer aged 35 or less (<= 35 years) were selected for the study. In total 211 cases were included. Pathologic features; histologic subtypes, grade, lymphovascular invasion, axillary involvement, and stage were recorded for each. Results: The most common subtype was luminal B (36.5%), followed by luminal A (30.8%), triple negative (23.2%) and HER2+(9.5%) subtypes. Twelve percent of the patients had stage 4, 32.7% had stage 3, 46.4% had stage 2, and 6.2% had stage 1 disease at the time of diagnosis. Mean tumour diameter was 3.87 cm (range 0.3-13 cm). The axillary lymph nodes were positive in 74.4% of the patients, while lympho-vascular invasion was seen in 56.4%. Some 9.5% of patients had grade 1, 51.2% had grade 2, and 31.8% had grade 3 tumors. Conclusions: Young women with breast cancer in Turkey are more likely to present with luminal B subtype. Tumors in young women are more likely to present with advanced disease, to be high grade and and to have more lymphovascular invasion. Further research should focus on whether we need new treatment strategies for young patients with breast carcinoma.en_US
dc.identifier.doi10.7314/APJCP.2014.15.16.6665en_US
dc.identifier.endpage6668en_US
dc.identifier.issn1513-7368en_US
dc.identifier.issue16en_US
dc.identifier.pmid25169505en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage6665en_US
dc.identifier.urihttps://dx.doi.org/10.7314/APJCP.2014.15.16.6665
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30674
dc.identifier.volume15en_US
dc.identifier.wosWOS:000343832900034en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherASIAN PACIFIC ORGANIZATION CANCER PREVENTIONen_US
dc.relation.ispartofASIAN PACIFIC JOURNAL OF CANCER PREVENTIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectYoung patientsen_US
dc.subjectbreast canceren_US
dc.subjectmolecular characteristicsen_US
dc.subjectclinicopathological featuresen_US
dc.subjectTurkeyen_US
dc.titleClinicopathologic Features and Molecular Subtypes of Breast Cancer in Young Women (Age <= 35)en_US
dc.typeArticleen_US

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