Evaluation of Cholinesterase Inhibitory and Antioxidant Activities of Wild and Cultivated Samples of Sage (Salvia fruticosa) by Activity-Guided Fractionation

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dc.contributor.authorSenol, Fatma Sezer
dc.contributor.authorOrhan, Ilkay Erdogan
dc.contributor.authorErdem, Sinem Aslan
dc.contributor.authorKartal, Murat
dc.contributor.authorSener, Bilge
dc.contributor.authorKan, Yuksel
dc.contributor.authorCelep, Ferhat
dc.date.accessioned2020-03-26T18:14:33Z
dc.date.available2020-03-26T18:14:33Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn European folk medicine, Salvia species have traditionally been used to enhance memory. In our previous study of 55 Salvia taxa, we explored significant anticholinesterase activity of cultivated S. fruticosa. In this study, we compared the inhibitory activity of dichloromethane, ethyl acetate, and ethanol extracts of 3 wild-grown samples and 1 cultivated sample of S. fruticosa against acetylcholinesterase and butyrylcholinesterase enzymes (which are associated with pathogenesis of Alzheimer's disease) by using the spectrophotometric Ellman method. Antioxidant activities were assessed by determining 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity, iron-chelating capacity, and ferric-reducing antioxidant power. The dichloromethane extract of the cultivated sample was then subjected to fractionation by using open column chromatography and medium-pressure liquid chromatography to obtain the most active fraction by activity-guided fractionation. All fractions and subfractions were tested in the same manner, and inactive subfractions were discarded. The essential oil of the cultivated sample was analyzed by gas chromatography-mass spectrometry.en_US
dc.description.sponsorshipTurkish Scientific and Technical Research Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK-TBAG-104T450]en_US
dc.description.sponsorshipF.S.S. expresses gratitude to the Turkish Scientific and Technical Research Council (TUBITAK) for the scholarship provided for PhD program. Financial support for the field trips was provided by Scientific and Technical Research Council of Turkey (TUBITAK-TBAG-104T450).en_US
dc.identifier.doi10.1089/jmf.2010.0158en_US
dc.identifier.endpage1483en_US
dc.identifier.issn1096-620Xen_US
dc.identifier.issue11en_US
dc.identifier.pmid21663475en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1476en_US
dc.identifier.urihttps://dx.doi.org/10.1089/jmf.2010.0158
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26458
dc.identifier.volume14en_US
dc.identifier.wosWOS:000296748800026en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMARY ANN LIEBERT INCen_US
dc.relation.ispartofJOURNAL OF MEDICINAL FOODen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectantioxidant activityen_US
dc.subjectcholinesterase inhibitionen_US
dc.subjectchromatographyen_US
dc.subjectessential oilen_US
dc.subjectSalvia fruticosaen_US
dc.titleEvaluation of Cholinesterase Inhibitory and Antioxidant Activities of Wild and Cultivated Samples of Sage (Salvia fruticosa) by Activity-Guided Fractionationen_US
dc.typeArticleen_US

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