Effects of Sildenafil and Vardenafil on Erectile Dysfunction and Health-Related Quality of Life in Haemodialysis Patients: A Prospective Randomized Crossover Study

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dc.contributor.authorTürk, Süleyman
dc.contributor.authorSolak, Yalçın
dc.contributor.authorKan, Seyfullah
dc.contributor.authorAtalay, Hüseyin
dc.contributor.authorKılınç, Mehmet
dc.contributor.authorAğca, Erhan
dc.contributor.authorBodur, Said
dc.date.accessioned2020-03-26T17:48:20Z
dc.date.available2020-03-26T17:48:20Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground. Erectile dysfunction (ED) is prevalent in end-stage renal disease (ESRD) and has been associated with impaired health-related quality of life (HRQoL). HRQoL, in turn, is related to morbidity and mortality in ESRD patients. Previous studies have shown improved HRQoL with ED treatment using sildenafil and vardenafil. However, no study has examined the effects of sildenafil or vardenafil on HRQoL in impotent ESRD patients. Furthermore, vardenafil has never been tested and its safety profile has not been determined in ESRD patients. The aim of this randomized crossover study was to compare the effects of sildenafil and vardenafil on measures of HRQoL and on ED scores as well as to determine the safety profile of vardenafil in ESRD patients. Methods. In 32 haemodialysis patients with impotence, ED and HRQoL were evaluated by the International Index of Erectile Function (IIEF-5) and the 36-item Short-Form Health (SF-36) surveys, respectively. Patients were randomized into sildenafil and vardenafil groups. After a 4-week treatment and 2-week washout periods, crossover was performed and an additional 4-week treatment was administered. IIEF-5 and SF-36 surveys were given before and after each treatment period. Adverse effects were evaluated by interview. Friedman tests and Bonferroni-adjusted Wilcoxon signed-rank tests were used to compare groups and for post hoc analysis, respectively. Results. IIEF-5 and SF-36 scores were significantly improved by both sildenafil and vardenafil compared to pretreatment values. There were no differences between sildenafil and vardenafil with respect to the studied parameters. Adverse effect profiles were also similar. No patient dropped out because of side effects. Conclusions. Sildenafil and vardenafil caused similar improvements in ED and HRQoL in haemodialysis patients. Vardenafil was well tolerated in our patient population.en_US
dc.identifier.citationTürk, S., Solak, Y., Kan, S., Atalay, H., Kılınç, M., Ağca, E., Bodur, S., (2010). Effects of Sildenafil and Vardenafil on Erectile Dysfunction and Health-Related Quality of Life in Haemodialysis Patients: A Prospective Randomized Crossover Study. Nephrology Dialysis Transplantation, 1-4. Doi: 10.1093/ndt/gfq243
dc.identifier.doi10.1093/ndt/gfq243en_US
dc.identifier.endpage4en_US
dc.identifier.issn0931-0509en_US
dc.identifier.pmid20466680en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://dx.doi.org/10.1093/ndt/gfq243
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24866
dc.identifier.wosWOS:000283683900041en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTürk, Süleyman
dc.institutionauthorSolak, Yalçın
dc.institutionauthorKan, Seyfullah
dc.institutionauthorAtalay, Hüseyin
dc.institutionauthorKılınç, Mehmet
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofNephrology Dialysis Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectErectile dysfunctionen_US
dc.subjectHaemodialysisen_US
dc.subjectHealth-related quality of lifeen_US
dc.subjectSildenafilen_US
dc.subjectVardenafilen_US
dc.titleEffects of Sildenafil and Vardenafil on Erectile Dysfunction and Health-Related Quality of Life in Haemodialysis Patients: A Prospective Randomized Crossover Studyen_US
dc.typeArticleen_US

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