Phytochemical Fingerprinting and In Vitro Bioassays of the Ethnomedicinal Fern Tectaria coadunata (J. Smith) C. Christensen from Central Nepal

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dc.contributor.authorShrestha, Shyam Sharan
dc.contributor.authorSut, Stefania
dc.contributor.authorDi Marco, Serena Barbon
dc.contributor.authorZengin, Gökhan
dc.contributor.authorGandin, Valentina
dc.contributor.authorDe Franco, Michele
dc.contributor.authorPant, Deepak Raj
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorDall'Acqua, Stefano
dc.contributor.authorRajbhandary, Sangeeta
dc.date.accessioned2020-03-26T20:19:09Z
dc.date.available2020-03-26T20:19:09Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractTectaria coadunata, an ethnomedicinal fern used in Nepal to treat a large number of diseases, has been poorly studied with regard to its phytochemical composition and possible bioactivity. This study was performed with the aim of supporting traditional medicine as a new source of bioactive constituents. Phytochemical compositions of methanol extracts were determined by nuclear magnetic resonance (NMR), liquid chromatography-diode array detector-mass spectrophotometry (LC-DAD-MS), and liquid chromatography-fluorescence-mass spectrometry. Quali-quantitative data revealed large amount of procyanidins, mainly of the A-type, as well as eriodictyol-7-O-glucuronide and luteolin-7-O-glucoronide as main constituents. The antioxidant, cytotoxic, and inhibitory activity of five enzymes that are implicated in human diseases was evaluated for the extract and fractions. High free-radical scavenging activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays and inhibitory activities against cholinesterases and tyrosinase were observed. Furthermore, a moderate cytotoxic effect was observed on the 2008 and BxPC3 cell lines. Overall results showed potential usefulness of this fern as a source of phytochemicals for pharmaceutical uses.en_US
dc.identifier.citationShrestha, S. S., Sut, S., Barbon Di Marco, S., Zengin, G., Gandin, V., De Franco, M., Pant, D.R., Mahomoodally, M. F., Dall'Acqua, S., Rajbhandary, S. (2019). Phytochemical Fingerprinting And İn Vitro Bioassays Of The Ethnomedicinal Fern Tectaria Coadunata (J. Smith) C. Christensen From Central Nepal. Molecules, 24,(24), 4457.
dc.identifier.doi10.3390/molecules24244457en_US
dc.identifier.issn1420-3049en_US
dc.identifier.issue24en_US
dc.identifier.pmid31817382en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.3390/molecules24244457
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38109
dc.identifier.volume24en_US
dc.identifier.wosWOS:000507299600035en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofMOLECULESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTectaria coadunataen_US
dc.subjectantioxidanten_US
dc.subjectmedicinal fernen_US
dc.subjectchromatographyen_US
dc.subjectprocyanidinsen_US
dc.subjectflavonolsen_US
dc.titlePhytochemical Fingerprinting and In Vitro Bioassays of the Ethnomedicinal Fern Tectaria coadunata (J. Smith) C. Christensen from Central Nepalen_US
dc.typeArticleen_US

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