Effects of CoQ10 supplementation and swimming training on exhaustive exercise-induced oxidative stress in rat heart

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dc.contributor.authorOkudan, N.
dc.contributor.authorRevan, S.
dc.contributor.authorBalci, S. S.
dc.contributor.authorBelviranli, M.
dc.contributor.authorPepe, H.
dc.contributor.authorGokbel, H.
dc.date.accessioned2020-03-26T18:25:11Z
dc.date.available2020-03-26T18:25:11Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study examined the combined effects of swimming training and coenzyme Q(10) (CoQ(10)) supplementation on exhaustive exercise-induced oxidative stress in rat heart. The study was carried out with 4-month-old young adult male Wistar rats. Sixty four rats were divided mainly into two groups: trained and control. Each group was further divided into four subgroups: rest, exhausted, rest with CoQ(10), exhausted with CoQ(10). The training program consisted of swimming one hour each day, five days a week, for six weeks. At the end of sixth week, rats in exhausted exercise group were forced to swim until exhaustion and then they were immediately sacrificed, while rats in rest group were sacrificed at rest. Training alone or in combination with CoQ(10) supplementation reduced to increasing MDA levels due to exhaustive exercise in rat heart (p<0.05). The trained-rest with CoQ(10) group showed lower 8-OHdG levels than the control-rest with CoQ(10) group. Exhaustive exercise effect was significant on SOD activity. Exhaustive exercise increased GSH levels in control groups while decreased GSH levels in training groups (p<0.05). In conclusion, the results suggest that CoQ(10) supplementation combined with training may inhibit lipid peroxidation and DNA damage in the heart tissue. Also, it can be said that SOD activity and GSH levels were not influenced by CoQ(10) supplementation (Fig. 4, Tab. 1, Ref. 69). Full Text in PDF www.elis.sk.en_US
dc.description.sponsorshipSelcuk University, Scientific Research Projects (S.U.-BAP, Konya, Turkey)Selcuk University [6401032]en_US
dc.description.sponsorshipThis study was supported by Selcuk University, Scientific Research Projects (S.U.-BAP, Konya, Turkey; Project No. 6401032). This research has been presented in part at the 3th Symposium of Exercise Physiology on May 13-14, 2011, in Adana, Turkey.en_US
dc.identifier.doi10.4149/BLL_2012_089en_US
dc.identifier.endpage399en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue7en_US
dc.identifier.pmid22794511en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2012_089
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27969
dc.identifier.volume113en_US
dc.identifier.wosWOS:000306941100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCoQ(10)en_US
dc.subjectswimming trainingen_US
dc.subjectoxidative stressen_US
dc.titleEffects of CoQ10 supplementation and swimming training on exhaustive exercise-induced oxidative stress in rat hearten_US
dc.typeArticleen_US

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