Glutathione S-Transferase M1 and T1 Polymorphisms in Turkish Patients With Varicocele
Yükleniyor...
Dosyalar
Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
WILEY-BLACKWELL
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Several studies have shown that high oxidative stress levels are associated with varicocele. The GST (glutathione S-transferase) family of genes is critical in the protection of cells from oxidative stress because they utilise as substrates a wide variety of products of oxidative stress. The objective of this study was to assess the relationship between genetic polymorphism in GST-M1 and GST-T1 and varicocele using 109 varicocele patients and 123 controls. Varicoceles were clinically graded as Grade 1, Grade 2 and Grade 3. GST-M1 and GST-T1 genes were determined by polymerase chain reaction. Although the GST-M1 null genotype was higher in Grade 3 than in Grade 1, 2 and controls, there were no statistical differences between control group and varicocele groups according to GST-M1 and GST-T1 null genotype. Men with varicocele do not have more GST-M1 and GST-T1 null polymorphisms than men without varicocele. Additional studies are needed to assess the exact mechanism by which the varicocele corresponds to elevated ROS levels.
Açıklama
Anahtar Kelimeler
GST-M1, GST-T1, Genotype, Varicocele
Kaynak
Andrologia
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
44
Sayı
1
Künye
Acar, H., Kılınç, M., Güven, S., İnan, Z., (2012). Glutathione S-Transferase M1 and T1 Polymorphisms in Turkish Patients With Varicocele. Andrologia, 44(1), 34-37. Doi: 10.1111/j.1439-0272.2010.01103.x
