Association of Circulating Irisin with Insulin Resistance and Oxidative Stress in Obese Women

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dc.contributor.authorBelviranli, M.
dc.contributor.authorOkudan, N.
dc.contributor.authorCelik, F.
dc.date.accessioned2020-03-26T19:23:10Z
dc.date.available2020-03-26T19:23:10Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIrisin is a myokine/adipokine with potential role in obesity and diabetes. The purpose of the present study was to assess irisin levels and its association with insulin resistance and oxidative stress markers in premenopausal normal-weight and obese women. Ten obese (mean body mass index, 32.65 +/- 3.04kgm(-2)) and 10 normal-weight (23.00 +/- 2.23kgm(-2)) premenopausal women were involved in the present study. Anthropometric, and body composition parameters, blood chemistry, oxidative stress markers, and irisin concentrations of different groups were measured. Correlation analyses were performed between irisin and other measured parameters. Plasma irisin levels were lower in the obese group than the normal-weight group (p<0.05). Glucose, homeostasis model assessment index (HOMA-IR), and MDA levels in the obese group were higher than that in the normal-weight group (p<0.05). Plasma irisin was negatively correlated with insulin (r=-0.648, p<0.05), HOMA-IR (r=-0.664, p<0.05) and MDA (r=-0.690, p<0.05). These data suggest that irisin levels are decreased with obesity, and irisin may have an antidiabetic and antioxidant effects.en_US
dc.identifier.doi10.1055/s-0042-116155en_US
dc.identifier.endpage657en_US
dc.identifier.issn0018-5043en_US
dc.identifier.issn1439-4286en_US
dc.identifier.issue10en_US
dc.identifier.pmid27632149en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage653en_US
dc.identifier.urihttps://dx.doi.org/10.1055/s-0042-116155
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33294
dc.identifier.volume48en_US
dc.identifier.wosWOS:000385917800005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGEORG THIEME VERLAG KGen_US
dc.relation.ispartofHORMONE AND METABOLIC RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectirisinen_US
dc.subjectobesityen_US
dc.subjectinsulin resistanceen_US
dc.subjectoxidative stressen_US
dc.titleAssociation of Circulating Irisin with Insulin Resistance and Oxidative Stress in Obese Womenen_US
dc.typeArticleen_US

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