Milk and Blood Pharmacokinetics of Tylosin and Tilmicosin following Parenteral Administrations to Cows

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dc.contributor.authorAvci, Tulay
dc.contributor.authorElmas, Muammer
dc.date.accessioned2020-03-26T18:51:30Z
dc.date.available2020-03-26T18:51:30Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study is to determine the pharmacokinetics of tylosin and tilmicosin in serum and milk in healthy Holstein breed cows (n = 12) and reevaluate the amount of residue in milk. Following the intramuscular administration of tylosin, the maximum concentrations (C-max) in serum and milk were found to be 1.30 +/- 0.24 and 4.55 +/- 0.23 mu g/mL, the time required to reach the peak concentration (C-max) was found to be 2nd and 4th h, and elimination half-lives (t(1/2 beta)) were found to be 20.46 +/- 2.08 and 26.36 +/- 5.55 h, respectively. Following the subcutaneous administration of tilmicosin, the C-max in serum and milk were found to be 0.86 +/- 0.20 and 20.16 +/- 1.13 mu g/mL, the C-max was found to be 1st and 8th h, and the t(1/2 beta) were found to be 29.94 +/- 6.65 and 43.02 +/- 5.18 h, respectively. AUC(milk) /AUC(serum) and Cmax-milk /Cmax-serum rates, which are indicators for determining the rate of drugs that pass into milk, were, respectively, calculated as 5.01 +/- 0.72 and 3.61 +/- 0.69 for tylosin and 23.91 +/- 6.38 and 20.16 +/- 1.13 for tilmicosin. In conclusion, it may be stated that milk concentration of tylosin after parenteral administration is higher than expected like tilmicosin and needs more withdrawal period for milk than reported.en_US
dc.description.sponsorshipScientific Research Projects Coordinatorship of Selcuk University, Konya, TurkeySelcuk University [08202007]; Food and Feed Research Department under the Directorate General for Agricultural Research and Policies of the Ministry of Food, Agriculture and Livestock of the Republic of TurkeyGida Tarim Ve Hayvancilik Bakanligi [TAGEM/GY/09/03/01/163]en_US
dc.description.sponsorshipThis research was summarized from a Ph.D. thesis and was supported by the Scientific Research Projects Coordinatorship of Selcuk University, Konya, Turkey (Project no. 08202007) and the Food and Feed Research Department under the Directorate General for Agricultural Research and Policies of the Ministry of Food, Agriculture and Livestock of the Republic of Turkey (Project no. TAGEM/GY/09/03/01/163).en_US
dc.identifier.doi10.1155/2014/869096en_US
dc.identifier.issn1537-744Xen_US
dc.identifier.pmid25177733en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1155/2014/869096
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30986
dc.identifier.wosWOS:000343512500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHINDAWI PUBLISHING CORPORATIONen_US
dc.relation.ispartofSCIENTIFIC WORLD JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleMilk and Blood Pharmacokinetics of Tylosin and Tilmicosin following Parenteral Administrations to Cowsen_US
dc.typeArticleen_US

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