Mechanical intestinal cleansing and antibiotic prophylaxis for preventing bacterial translocation during the pringle maneuver in rabbits

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dc.contributor.authorErenoglu, Bulent
dc.contributor.authorGokturk, Huseyin Savas
dc.contributor.authorKucukkartallar, Tevfik
dc.contributor.authorSahin, Mustafa
dc.contributor.authorTekin, Ahmet
dc.contributor.authorTatkan, Yuksel
dc.contributor.authorBodur, Sait
dc.date.accessioned2020-03-26T18:15:14Z
dc.date.available2020-03-26T18:15:14Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe investigated the effectiveness of mechanical intestinal cleansing and antibiotic prophylaxis in preventing bacterial translocation (BT) during the Pringle maneuver in rabbits. Forty-eight rabbits were allocated to one of the following four groups: a control group (group 1); an antibiotic group, given 100 mg/kg intravenous ceftizoxime (group 2); a mechanical intestinal cleansing group, given a Fleet enema (group 3); and a mechanical intestinal cleansing plus antibiotic group (group 4). After performing laparotomy, we dissected the portal region and turned the portal triad, using tape. Pringle maneuver was applied for 30 min in all groups. Blood samples were collected from the portal vein for blood culture before the Pringle maneuver. All groups underwent relaparotomy 30 min after the Pringle maneuver, to obtain portal blood, mesenteric lymph nodes (MLNs), and splenic tissue for culture. All cultures from the portal vein specimens taken before the Pringle maneuver were negative. The rate of bacterial isolation in the portal vein (P < 0.001), MLNs (P < 0.01), and splenic (P < 0.001) cultures was significantly lower in group 4 than in the other groups. It was also lower in group 3 than in groups 1 and 2 (P < 0.05 for all). The combination of mechanical intestinal cleansing and preoperative broad-spectrum antibiotics was most effective for preventing BT during the Pringle maneuver.en_US
dc.identifier.doi10.1007/s00595-010-4363-4en_US
dc.identifier.endpage828en_US
dc.identifier.issn0941-1291en_US
dc.identifier.issue6en_US
dc.identifier.pmid21626330en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage824en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00595-010-4363-4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26635
dc.identifier.volume41en_US
dc.identifier.wosWOS:000291056300014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofSURGERY TODAYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPringle maneuveren_US
dc.subjectAntibiotic prophylaxisen_US
dc.subjectMechanical intestinal cleansingen_US
dc.subjectBacterial translocationen_US
dc.titleMechanical intestinal cleansing and antibiotic prophylaxis for preventing bacterial translocation during the pringle maneuver in rabbitsen_US
dc.typeArticleen_US

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